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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

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Endpoint:
activated sludge respiration inhibition testing
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Study period:
2006
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Read across to Pigment Red 3 and Pigment Orange 5 – these are other substances in the Monoazo Red consortium which is a structural analogue
Justification for type of information:
Category of Monoazo Red Pigments (C.I. PIGMENT RED 3, C.I. PIGMENT RED 4, C.I. PIGMENT ORANGE 5)
1. HYPOTHESIS FOR THE CATEGORY APPROACH
A very similar chemical structure is the basis for similar physical-chemical properties as very low solubility in water (but also in organic solvents and lipophilic matrices) and non-degradability which lead to inert behaviour and negligible bioavailability. See attached PR4_CSR.doc in Section 13 (1.1.1. Category Definition and its members - Category Hypothesis).
2. CATEGORY APPROACH JUSTIFICATION
Monoazo Red Pigments do not exert toxic effects to aquatic, terrestrial and sediment organisms as well as bacteria. See attached PR4_CSR.doc in Section 13 (1.1.1. Category Definition and its members - Category Justification).
Qualifier:
according to guideline
Guideline:
OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Analytical monitoring:
not required
Vehicle:
no
Test organisms (species):
activated sludge, domestic
Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
3 h
Duration:
3 h
Dose descriptor:
EC50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Validity criteria fulfilled:
yes
Conclusions:
The test item is not toxic at concentrations ≤ 1000 mg/L to activated sludge of a municipal sewage treatment plant.
Endpoint:
activated sludge respiration inhibition testing
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Study period:
2007
Reliability:
1 (reliable without restriction)
Justification for type of information:
Category of Monoazo Red Pigments (C.I. PIGMENT RED 3, C.I. PIGMENT RED 4, C.I. PIGMENT ORANGE 5)
1. HYPOTHESIS FOR THE CATEGORY APPROACH
A very similar chemical structure is the basis for similar physical-chemical properties as very low solubility in water (but also in organic solvents and lipophilic matrices) and non-degradability which lead to inert behaviour and negligible bioavailability. See attached PR4_CSR.doc in Section 13 (1.1.1. Category Definition and its members - Category Hypothesis).
2. CATEGORY APPROACH JUSTIFICATION
Monoazo Red Pigments do not exert toxic effects to aquatic, terrestrial and sediment organisms as well as bacteria. See attached PR4_CSR.doc in Section 13 (1.1.1. Category Definition and its members - Category Justification).
Qualifier:
according to guideline
Guideline:
OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
GLP compliance:
yes (incl. QA statement)
Analytical monitoring:
not required
Vehicle:
no
Test organisms (species):
activated sludge, domestic
Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
3 h
Duration:
3 h
Dose descriptor:
EC50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Validity criteria fulfilled:
yes
Conclusions:
The test item is not toxic at concentrations <1000 mg/L to activated sludge from a municipal treatment plant

Description of key information

Neither C.I. Pigment Red 3 or C.I. Pigment Orange 5 are toxic at concentrations ≤ 1000 mg/L to activated sludge of a municipal sewage treatment plant.

Key value for chemical safety assessment

EC50 for microorganisms:
1 000 mg/L

Additional information