Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 222-883-3 | CAS number: 3648-18-8
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
EC50 > 1000 mg/L, NOEC 1000 mg/L, Dioctyltin oxide, OECD 209, Roulstone (2012).
EC50 > 1000 mg/L, NOEC 100 mg/L, Dioctylbis(pentane-2,4-dionate-O,O’)tin, OECD 209, Fiebig (2011).
Key value for chemical safety assessment
Additional information
Two studies are available for the read-across substances dioctyltin oxide and dioctylbis(pentane-2,4 -dionate-O,O')tin, which have been used to address this endpoint on a weight of evidence basis.
Roulstone (2012) performed an activated sludge respiration inhibition test using dioctyltin oxide. The study was performed under GLP conditions and to standardised guidelines. The rate of respiration was determined in the activated sewage sludge after 3 hours contact time and compared to data for the control and a reference item, 3,5-dichlorophenol. The effect of the test material on the respiration of activated sewage sludge gave a 3 hour EC50 value of greater than 1000 mg/L. The No Observed Effect Concentration (NOEC) after 3 hours exposure was 1000 mg/L. It was considered unnecessary and unrealistic to test at concentrations in excess of 1000 mg/L. No statistically significant toxic effects were shown at any of the test concentrations employed. It was therefore considered justifiable not to perform a definitive test.
Fiebig (2011) determined the effect on the respiration of activated sewage sludge micro-organisms after exposure to dioctylbis(pentane-2,4 -dionate-O,O')tin. The study was performed under GLP conditions and in line with standardised guidelines. The test was conducted under static conditions at nominal test concentrations of 10, 32, 100, 320 and 1000 mg/L with a 3 hour contact time. Under the conditions of the study the EC50 of the test material was determined to be greater than 1000 mg/L; the NOEC was determined to be 100 mg/L.
Since both studies were conducted with read across substances in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results they were assigned a reliability score of 2 according to the criteria of Klimisch (1997) and were considered suitable as an accurate reflection of the substance di-n-octyltin laurate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
