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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
toxicity to reproduction
Remarks:
other: summary of several reproductive toxicity studies
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: RTECS data are peer-reviewed.

Data source

Reference
Reference Type:
secondary source
Title:
Reproductive data (RTECS Number: KI7968000)
Author:
RTECS
Year:
1990
Bibliographic source:
http://ccinfoweb2.ccohs.ca/rtecs/Action.lasso?-database=rtecs&-layout=Display&-response=detail.html&-op=eq&RTECS+NUMBER=KI7968000&-search

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Rats received mesna intravenously during 9 (males) or 2 weeks (females) of the pre-mating period and thereafter they were treated 7 days after conception. Fertility (number of implants per female and total number of implants per corpora lutea) and preimplantation mortality and effects on embryo or foetus were studied. Dose level was 26880 mg/kg bw/entire exposure period.
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Reference substance name:
Mesna
EC Number:
243-285-9
EC Name:
Mesna
Cas Number:
19767-45-4
IUPAC Name:
sodium 2-sulfanylethanesulfonate

Test animals

Species:
rat

Administration / exposure

Route of administration:
intravenous
Doses / concentrations
Remarks:
Doses / Concentrations:
26880 mg/kg
Basis:
no data

Results and discussion

Results: P0 (first parental generation)

Effect levels (P0)

Dose descriptor:
other: TDLo
Effect level:
26 880 mg/kg bw (total dose)
Sex:
male/female
Basis for effect level:
other: Reproductive effects (fertility): preimplantation mortality (reduction in number of implants per female and total number of implants per corpora lutea); No other maternal effects or effects on embryo or foetus are reported.

Overall reproductive toxicity

Reproductive effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Mesna at a dose level of 26880 mg/kg bw (total dose) caused a reduction in the number of implants per female and total number of implants per corpora lutea.
Executive summary:

Mesna was studied for its reproductive toxicity potential in rats. Animals received mesna intravenously during pre-mating period (males 9 weeks and females 2 weeks). Thereafter females were treated until day 7 after conception. Mesna at a dose level of 26880 mg/kg bw (total dose) caused effects on fertility. Preimplantation mortality was observed: the number of implants per female and the total number of implants per corpora lutea were reduced. No other maternal effects or effects on embryo or foetus are reported.