Registration Dossier
Registration Dossier
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Reaction mass of Cobaltate(3-), bis[2-[[[3-[2-[1-[[(2-chlorophenyl)amino]carbonyl]-2-(oxo-κO)propyl]diazenyl-κN1]-4-(hydroxy-κO)phenyl]sulfonyl]amino]benzoato(3-)]-, sodium (1:3) and tetrasodium bis[2-[[[3-[[1-[(2-chloroanilino)carbonyl]-2-oxopropyl]azo]-4-hydroxyphenyl]sulphonyl]amino]benzoato(3-)]cobaltate(4-)
EC number: 941-792-6 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- flask method
- Specific details on test material used for the study:
- Identification: FAT 92368/Y
Appearance: Yellow powder - Water solubility:
- 182 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: pH unknown
- Conclusions:
- The water solubility of the test item at a temperature of 20 °C was determined to be 182 g/L.
- Executive summary:
The water solubility (cs) of FAT 92368/Y was assessed according to the flask method as specified in OECD test guideline 105. In the experiment, three flasks were prepared with about 1000 mg test item and 5 ml water. The batches were incubated for 24, 48 & 72 hours respectively and compared with blank using UV VIS. Based on the findings of the study, the water solubility (cs) of the test item at a temperature of 20 °C was determined to be 182 g/L.
Reference
Preliminary visual estimation of the n-octanol solubility
Appearance of the test mixtures in the preliminary test
| Amount of test item in mg | Volume in ml | Appearance of mixture |
| 100 | 0.10 | Undissolved |
| 0.50 | Dissolved | |
| 1.00 | Dissolved |
According to this preliminary test, the water solubility of the test item is >200 g/L and <1000 g/L.
Flask Method
Experiment | A | B | C | D(blank) |
Amount of test item (g) | 1 | 1 | 1 | -- |
Stirring time at 30 °C (h) | 24 | 48 | 72 | 72 |
Measured concentration (μg/ml) Aliquot: 5/0.02/10/0.5/10 | 18.5 | 18.2 | 18.0 | -- |
Solubility (g/l) | 185 | 182 | 180 | -- |
Average solubility A to C: 182 g/L.
Std deviation: 7.2 g/L.
Relative standard deviation: 4 %
Standard addition for recheck:
Standard | Measured concentration(μg/ml) | % Recovery |
Sample C + 15.3 μg of test item | 33.6 | 100.9 % |
The recovery of 100.9 % indicates a sufficient accuracy of the analytical method.
Description of key information
Water solubility of the substance was determined to be 182 g/L.
Key value for chemical safety assessment
- Water solubility:
- 182 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility (cs) of FAT 92368/Y was assessed according to the flask method as specified in OECD test guideline 105. In the experiment, three flasks were prepared with about 1000 mg test item and 5 ml water. The batches were incubated for 24, 48 & 72 hours respectively and compared with blank using UV VIS. Based on the findings of the study, the water solubility (cs) of the test item at a temperature of 20 °C was determined to be 182 g/L.
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