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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Limited methodological detail is provided; however the study is considered to be sufficiently reliable for the purposes of classification and labelling.

Data source

Reference
Reference Type:
publication
Title:
The Toxicity and Structure of Various Aromatic Fluorides
Author:
Tai,T., Yamashita, M., Takeda, M., and Naito, H.
Year:
1986
Bibliographic source:
Burgetaheir, A.W (ed.) Fluoride Official Quarterly Journal; Volume 19 no. 3; The International Society for Fluoride Research, Michigan, USA, 117-121

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
Principles of method if other than guideline:
2-trifluoromethylbenzoyl chloride was administered via microcylinder through a stomach tube. Syptoms were observed for 8 hours and deaths, symptoms and body weight were noted for 7 days. The median lethal dose (LD50) was calculated by the method of Litchfield and Wilcoxon as the standard of mortality to 72 hours following the administration.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
2-trifluoromethylbenzoyl chloride
IUPAC Name:
2-trifluoromethylbenzoyl chloride
Test material form:
other: liquid (oil)
Details on test material:
- Name of test material (as cited in study report):2-trifluoromethylbenzoyl chloride
- Physical state: liquid
- Analytical purity: >99% using gas chromatography

Test animals

Species:
rat
Strain:
Wistar
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: 7 weeks old
- Acclimation period: 1 week

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 +/- 1
- Humidity (%): 55 +/- 5
- Photoperiod (hrs dark / hrs light): 12 hrs dark / 12 hrs light

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
MAXIMUM DOSE VOLUME APPLIED: 1.5 ml/g body weight
Doses:
0.5-1.5 ml/g body weight
No. of animals per sex per dose:
No data
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: once daily
- Necropsy of survivors performed: no
Statistics:
The median lethal dose (LD50) was calculated by the method of Litchfield and Wilcoxon

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
8 200 mg/kg bw
Based on:
test mat.
95% CL:
7 000 - 9 500
Mortality:
No data
Clinical signs:
Decreased movement and 'weakness' were observed and resolvd within 3 days.
Body weight:
A slight decrease in body weight was noted
Gross pathology:
No data
Other findings:
No data

Any other information on results incl. tables

No data

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 for 2-trifluoromethylbenzoyl chloride is 8200 mg/kg bw therefore it is not classified according to Regulation (EC) No 1272/2008
Executive summary:

The results of this study indicate low acute oral toxicity of 2-trifluoromethylbenzoyl chloride in the rat. Based on an LD50 value of 8200 mg/kg bw, the substance does not require classification according to the CLP Regulation.