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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study performed under GLP. All relevant validity criteria were met.
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
inspected: March 2014; signature: May 2014
Type of method:
gas saturation method
Temp.:
25 °C
Vapour pressure:
0.716 Pa

Calculation of the Vapour Pressure

The vapour pressure at a given temperature can be calculated by determining the amount of material transported by a known amount of carrier gas.

Volume correction was completed by appropriate calculation methods described in the study report.

The Vapour pressure was subsequently calculated from:

Pvp = W x R x T / V x M

Pvp = vapour pressure [Pa] (calculated)

W = mass of evaporated test item [micro-grams] (from analysis)

R = gas constant = 8.314 J/K mol

T = temperature [K] (measured)

V = volume of nitrogen at test temperature [mL] (determined from flow rate)

M = molar mass of test item

 

From experimental data performed at the three test temperatures, the vapour pressure of the test item at 25 °C was calculated by interpolation of ln vapour pressure versus the reciprocal of test temperature (K).

 

The mass of transferred test item and corresponding vapour pressures are shown in the following table:

Saturator Column

Temp. / °C

Volume * / mL

Mass test substance in trap 1 / micro-grams

Mass test substance in trap 2 / micro-grams

Total mass test item / micro-grams

Vapour Pressure / Pa

Average Vapour Pressure / Pa (Standard Deviation)

A

25

37330

2175

n.d.

2175

0.707

0.706

(5.33x10^-3)

B

 

49774

2873

n.d.

2873

0.700

 

C

 

62217

3646

n.d.

3646

0.711

 

 

 

 

 

 

 

 

 

A

35

34453

4963

n.d.

4963

1.81

1.820

(1.18x10^-2)

B

 

45938

6649

n.d.

6649

1.82

 

C

 

57422

8379

n.d.

8379

1.83

 

 

 

 

 

 

 

 

 

A

45

35327

11157

n.d.

11157

4.09

0.706

(5.92x10^-2)

B

 

47102

14813

n.d.

14813

4.07

 

C

 

58878

18094

n.d.

18094

3.98

 

 

 

 

 

 

 

 

 

n.d. = None detected

*Corrected volume at test temperature as calculated under "Volume correction"

 

The vapour pressure at 25 °C was extrapolated from the vapour pressure curve (ln Pvp versus 1/T) and was calculated to 0.716 Pa.

The linearity of the detector response with respect to concentration was assessed over the concentration range of 10.3 to 517 mg/L. This was satisfactory with a correlation coefficient of 1.000 being obtained.

Conclusions:
The vapour pressure of the substance has been determined to be 0.716 Pa at 25 °C.
Executive summary:

The vapour pressure was determined using EU Method A.4 using the gas saturation method under GLP. To ensure saturation control, three different flow rates were used at each temperature. In the determination higher flow rates did not lead to lower vapour pressures, which means that the nitrogen was saturated with test substance under the conditions of the test. The mean vapour pressure was 25°C: 0.706 Pa;  35°C: 1.82 Pa and 45°C: 4.05 Pa respectively. The vapour pressure of the test substance was extrapolated from the vapour pressure curve (ln Pvp versus 1/T) and was calculated to be 0.716 Pa at 25°C.

Description of key information

Vapour Pressure: 0.716 Pa at 25 °C, EU Method A.4 – Gas Saturation Method, 2015

Key value for chemical safety assessment

Vapour pressure:
0.716 Pa
at the temperature of:
25 °C

Additional information

The vapour pressure was determined using EU Method A.4 using the gas saturation method under GLP. To ensure saturation control, three different flow rates were used at each temperature. In the determination higher flow rates did not lead to lower vapour pressures, which means that the nitrogen was saturated with test substance under the conditions of the test. The mean vapour pressure was 25°C: 0.706 Pa;  35°C: 1.82 Pa and 45°C: 4.05 Pa respectively. The vapour pressure of the test substance was extrapolated from the vapour pressure curve (ln Pvp versus 1/T) and was calculated to be 0.716 Pa at 25°C.