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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
other: surveillance data
Adequacy of study:
supporting study
Study period:
2015
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Association between serum polybrominated diphenyl ethers, new flame retardants and thyroid hormone levels for school students near a petrochemical complex, South China
Author:
Guo L-C et al
Year:
2018
Bibliographic source:
Chemosphere 202 (2018) 476-482

Materials and methods

Endpoint addressed:
other: blood concentrations and association to thyroid hormone levels
Principles of method if other than guideline:
no Guideline followed

Test material

Constituent 1
Chemical structure
Reference substance name:
Bis(2-ethylhexyl) tetrabromophthalate
EC Number:
247-426-5
EC Name:
Bis(2-ethylhexyl) tetrabromophthalate
Cas Number:
26040-51-7
Molecular formula:
C24H34Br4O4
IUPAC Name:
1,2-bis(2-ethylhexyl) 3,4,5,6-tetrabromobenzene-1,2-dicarboxylate

Results and discussion

Applicant's summary and conclusion

Executive summary:

In the this publication 174 school students living in a high pollution area (near a petrochemical complex) in South China (average age 10) were included to collect data and examine the influence of flame retardants on thyroid hormone (TH; serum T3 and T4; free T3 and T4 i.e. FT3 and FT4) and thyroid-stimulating hormone (TSH) levels. The median level of TBPH in the blood samples of school students was 6.6 ng/g lipid (mean 11 ng/g lipid). The frequency of detection is given with 83%. No control group was included in this investigation. The authors postulate positive/negative associations (linear trends) with the sums of blood concentrations of several chemicals via multiple linear regression analysis. No information is given on a potential activity of TBPH alone.