Registration Dossier
Registration Dossier
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EC number: 202-112-7 | CAS number: 91-97-4
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Remarks:
- Expert Judgement
- Type of information:
- other: Expert Judgement
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: expert statement
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Expert statement
- Principles of method if other than guideline:
- Rational argumentation based in physico-chemical properties of TODI and read-across from similar substance
Test material
- Reference substance name:
- 3,3'-dimethylbiphenyl-4,4'-diyl diisocyanate
- EC Number:
- 202-112-7
- EC Name:
- 3,3'-dimethylbiphenyl-4,4'-diyl diisocyanate
- Cas Number:
- 91-97-4
- Molecular formula:
- C16H12N2O2
- IUPAC Name:
- 3,3'-dimethylbiphenyl-4,4'-diyl diisocyanate
- Test material form:
- solid
Constituent 1
- Radiolabelling:
- other: not applicable
Test animals
- Details on test animals or test system and environmental conditions:
- not applicable
Administration / exposure
- Details on exposure:
- not applicable
- Duration and frequency of treatment / exposure:
- not applicable
Doses / concentrations
- Remarks:
- Doses / Concentrations:
not applicable
- No. of animals per sex per dose / concentration:
- not applicable
- Positive control reference chemical:
- not applicable
- Details on study design:
- not applicable
- Details on dosing and sampling:
- not applicable
- Statistics:
- not applicable
Results and discussion
- Preliminary studies:
- not applicable
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Data on the absorption or the metabolic fate and thus information on the toxicokinetics in humans of absorbed TODI is very limited.
No information is available on the toxicokinetics of TODI or e.g. "MDI" (methylene diphenyl diisocyanate, similar compound to TODI) following oral exposure in animals. But due to its high reactivity, orally ingested TODI will undergo spontaneous hydrolysis upon reaching the stomach as degradation products that are insoluble in water and thus TODI is not likely to cross gastrointestinal-tract membranes. Taken together, absorption in the gastrointestina-tract of TODI and consequently bioavailability is rather unlikely. - Details on distribution in tissues:
- no data available
- Details on excretion:
- Excretion is likely to occur in form of GSH-conjugates. It is assumed to appear mainly via faeces (similar as shown in a study with MDI: 5% via urine and 79% in faeces).
Metabolite characterisation studies
- Details on metabolites:
- no data available
Bioaccessibility (or Bioavailability)
- Bioaccessibility (or Bioavailability) testing results:
- no data available
Any other information on results incl. tables
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
