Previous Testing Proposals

Previous Testing Proposals

Previous Testing Proposals

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

There are currently no ongoing consultations.
 
δ-valerolactone 208-807-1 542-28-9 Reproductive toxicity (pre-natal developmental toxicity) 14/08/2014 28/09/2014 Details
α-methyl-1,3-benzodioxole-5-propionaldehyde 214-881-6 1205-17-0 Reproductive toxicity (extended one-generation reproductive toxicity study) 31/01/2023 17/03/2023 Details
α,α,α',α'-tetramethylxylene-α,α-diol 248-256-4 27138-01-8
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
14/08/2014
14/08/2014
28/09/2014
28/09/2014
Details
Zirconium dioxide 215-227-2 1314-23-4 Reproductive toxicity (pre-natal developmental toxicity) 15/04/2011 30/05/2011 Details
Zinc, O,O-mixed (iso-Bu), (iso-Pr), (pentyl) phosphorodithioate 820-225-5 101747-77-7
Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: testing proposed with [Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts] (EC 270-608-0)
Reproductive toxicity (pre-natal developmental toxicity) “|| Note: testing proposed with [Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts] (EC 270-608-0)
Sub-chronic toxicity (90-day): oral “|| Note: testing proposed with [Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts] (EC 270-608-0)
26/04/2019
26/04/2019
26/04/2019
10/06/2019
10/06/2019
10/06/2019
Details
Zinc, bis[O,O-bis(1-methylethyl) phosphorodithioato-.kappa.S]bis(cyclohexanamine)-, (T-4)- 809-986-4 52585-16-7 Genetic toxicity in vivo 18/06/2018 02/08/2018 Details
Zinc O,O,O',O'-tetrakis(1,3-dimethylbutyl) bis(phosphorodithioate) 218-679-9 2215-35-2
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with, zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), and Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), and zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5)
21/12/2021
21/12/2021
21/12/2021
04/02/2022
04/02/2022
04/02/2022
Details
Zinc O,O,O',O'-tetrakis(1,3-dimethylbutyl) bis(phosphorodithioate) 218-679-9 2215-35-2
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Testing proposed according to a plan for the ZDDP category
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Testing proposed according to a plan for the ZDDP category.
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) Testing proposed according to a plan for the ZDDP category.“
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
Details
Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) 230-257-6 6990-43-8
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
21/12/2021
21/12/2021
21/12/2021
04/02/2022
04/02/2022
04/02/2022
Details
Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) 230-257-6 6990-43-8
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
Details
Zinc methacrylate 236-144-8 13189-00-9 Genetic toxicity in vivo 01/03/2023 17/04/2023 Details
Zinc bis[O-(6-methylheptyl)] bis[O-(sec-butyl)] bis(dithiophosphate) 298-577-9 93819-94-4
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
Details
Zinc bis[O-(2-ethylhexyl)] bis[O-(isobutyl)] bis(dithiophosphate) 247-810-2 26566-95-0
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
04/10/2018
04/10/2018
19/11/2018
19/11/2018
Details
Zinc bis[O-(2-ethylhexyl)] bis[O-(isobutyl)] bis(dithiophosphate) 247-810-2 26566-95-0
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with another ZDDP category member to be determined based on outcome of other testing proposals
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), and Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), and Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6)
21/12/2021
21/12/2021
21/12/2021
04/02/2022
04/02/2022
04/02/2022
Details
zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) 224-235-5 4259-15-8
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with the substance and with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), and Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with the substance and with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8)
21/12/2021
21/12/2021
21/12/2021
04/02/2022
04/02/2022
04/02/2022
Details
zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) 224-235-5 4259-15-8
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0); CAS 68547-79-4) "Testing Proposed according to a plan for the ZDDP category"
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
Details
Zinc bis[bis(tetrapropylenephenyl)] bis(hydrogen dithiophosphate) 234-277-6 11059-65-7
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
Details
Zinc bis[bis(dodecylphenyl)] bis(dithiophosphate) 259-048-8 54261-67-5
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
04/10/2018
04/10/2018
19/11/2018
19/11/2018


Details
Zinc bis(O,O-diisooctyl) bis(dithiophosphate) 249-109-7 28629-66-5
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), and Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6)
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0), Zinc O,O,O',O'-tetrabutyl bis(phosphorodithioate) (EC 230-257-6), Phosphorodithioic acid, mixed O,O-bis(1,3-dimethylbutyl and iso-Pr) esters, zinc salts (EC 283-392-8), Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts (EC 272-723-1), and Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (EC 224-235-5)
21/12/2021
21/12/2021
21/12/2021
04/02/2022
04/02/2022
04/02/2022
Details
Zinc bis(O,O-diisooctyl) bis(dithiophosphate) 249-109-7 28629-66-5
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts (EC 270-608-0) "Testing proposed according to a plan for the ZDDP category.“
04/10/2018
04/10/2018
04/10/2018
19/11/2018
19/11/2018
19/11/2018
Details
Zinc bis(diethyldithiocarbamate) 238-270-9 14324-55-1 Reproductive toxicity (extended one-generation reproductive toxicity study) 10/08/2018 24/09/2018 Details
Zinc bis(benzenesulphinate) 246-148-1 24308-84-7 Genetic toxicity in vivo 25/05/2020 09/07/2020 Details
Yttrium zirconium oxide 264-885-7 64417-98-7 Reproductive toxicity (pre-natal developmental toxicity) 29/04/2014 13/06/2014 Details
Ytterbium (III) oxide 215-234-0 1314-37-0 Genetic toxicity in vivo 23/11/2020 07/01/2021 Details
Xylene 215-535-7 1330-20-7 Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Reaction mass of ethylbenzene and xylene (EC no. 905-588-0) 31/01/2023 17/03/2023 Details
Xylene 215-535-7 1330-20-7 Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: testing proposed with Reaction mass of ethylbenzene and xylene (EC No 905-588-0) 01/03/2023 17/04/2023 Details
Vinylene carbonate 212-825-5 872-36-6
Genetic toxicity in vivo
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
20/05/2021
20/05/2021
20/05/2021
05/07/2021
05/07/2021
05/07/2021
Details
Vinylene carbonate 212-825-5 872-36-6 Reproductive toxicity (pre-natal developmental toxicity) 25/11/2021 10/01/2022 Details
Vinyl neononanoate 259-160-7 54423-67-5 Reproductive toxicity (extended one-generation reproductive toxicity study) 28/02/2018 16/04/2018 Details
Vinyl neononanoate 259-160-7 54423-67-5 Reproductive toxicity (pre-natal developmental toxicity) // Note: testing proposed on rabbits 21/03/2014 05/05/2014 Details
Vinyl neononanoate 259-160-7 54423-67-5 Sub-chronic toxicity (90 day): oral 16/05/2012 02/07/2012 Details
Vinyl laurate 218-414-7 2146-71-6 Sub-chronic toxicity (90-day): oral 16/05/2011 30/06/2011 Details
Vinyl ethylene carbonate 700-261-7 4427-96-7 Sub-chronic toxicity (90-day): oral 30/06/2023 14/08/2023 Details
Vinyl 2-ethylhexanoate 202-297-4 94-04-2 Reproductive toxicity (extended one-generation reproductive toxicity study) 26/10/2022 12/12/2022 Details
Vinyl 2-ethylhexanoate 202-297-4 94-04-2 Reproductive toxicity (two-generation reproductive toxicity) 14/10/2011 28/11/2011 Details
Vanadium oxide sulphate 248-652-7 27774-13-6
Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with sodium metavanadate (EC 237-272-7)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with sodium metavanadate (EC 237-272-7)
01/04/2022
01/04/2022
16/05/2022
16/05/2022
Details
Vanadium dioxide 234-841-1 12036-21-4
Reproductive toxicity (extended one-generation reproductive toxicity study)||Note: : testing proposed with Sodium metavanadate (EC no. 237-272-7)
Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Sodium metavanadate (EC no. 237-272-7)
16/06/2022
16/06/2022
01/08/2022
01/08/2022
Details
Ureidopropyltrialkoxysilane 449-160-7 116912-64-2
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
25/06/2015
25/06/2015
10/08/2015
10/08/2015
Details
Urea, N-octyl-N'-[4-[[4-[[(octylamino)carbonyl]amino]phenyl]methyl]phenyl]-Urea, N-[4-[[4[(octadecylamino)carbonyl]amino]phenyl]methyl]phenyl]-N’-octyl 445-760-8 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
31/07/2015
31/07/2015
14/09/2015
14/09/2015
Details
Undecane 214-300-6 1120-21-4 Reproductive toxicity (two-generation reproductive toxicity) 25/06/2012 09/08/2012 Details
undec-10-enoic acid 203-965-8 112-38-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
20/05/2021
20/05/2021
05/07/2021
05/07/2021
Details
undec-10-enoic acid 203-965-8 112-38-9 Long-term toxicity to fish 16/10/2014 01/12/2014 Details
Trometamol 201-064-4 77-86-1
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 2-amino-1,3-propanediol
Sub-chronic toxicity (90-day): oral || Note: testing proposed with 2-amino-1,3-propanediol
17/06/2014
17/06/2014
01/08/2014
01/08/2014
Details
tri{[(2s)-1-ethoxy-1-oxopropan-2-yl]oxy}(vinyl)silane 701-301-6 -
Reproductive toxicity (pre-natal developmental toxicity)
Sub-chronic toxicity (90-day): oral
27/05/2019
27/05/2019
11/07/2019
11/07/2019
Details
Trixylyl phosphate 246-677-8 25155-23-1 Bioaccumulation aquatic / sediment 02/09/2011 17/10/2011 Details
Trisodium 4-amino-5-hydroxy-3-[[4-[[2-oxo-1-[(phenylamino)carbonyl]propyl]azo]phenyl]azo]-6-[(4-sulphonato-1-naphthyl)azo]naphthalene-2,7-disulphonate 279-093-7 79135-92-5 Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant. 21/01/2021 08/03/2021 Details
trisodium 2-(2-sulfoethoxy)ethane-1-sulfonate ethenesulfonate 700-978-5 - Reproductive toxicity (extended one-generation reproductive toxicity study) Note: testing proposed with Sodium ethylenesulphonate (EC No. 221-242-5) 03/05/2023 19/06/2023 Details
Tris[4-(diethylamino)phenyl]methylium acetate 263-974-8 63157-72-2 Reproductive toxicity (pre-natal developmental toxicity) 15/07/2011 29/08/2011 Details
tris[2-[2-(2-methoxyethoxy)ethoxy]ethyl] orthoborate 250-418-4 30989-05-0
Reproductive toxicity (pre-natal developmental toxicity)
Reproductive toxicity (two-generation reproductive toxicity)
Sub-chronic toxicity (90-day): oral
28/02/2011
28/02/2011
28/02/2011
14/04/2011
14/04/2011
14/04/2011
Details
tris[2-[2-(2-methoxyethoxy)ethoxy]ethyl] orthoborate 250-418-4 30989-05-0
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
29/04/2016
29/04/2016
13/06/2016
13/06/2016
Details