Registration Dossier
Registration Dossier
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EC number: 629-719-3 | CAS number: 1219010-04-4
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The 21d EC50 daphnia magna of 290 µg/L (parental mortality, OECD 211, river water test, reliability 1) is used as key value for the acute toxicity to aquatic invertebrates in the chemical safety assessment.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 290 µg/L
Additional information
Acute toxicity tests are available for daphnia magna for various alkyl-1,3 -diamines with C12 -18 chains (reliability 2 and 3).
The lowest 48h EC50 for Daphnia magna of 6.2 ug/L was determined in a test with the glassware presoaked overnight. At that time it was thought that this approach would compensate the loss of the substance to glassware. Later on the use of LC-MS/MS techniques to quantify the substance down to 0.5 µg/L, showed that presaturation is leading to test concentrations which are higher than nominal. Therefore this value has not been selected as key value.
The acute toxicity tests were conducted in a period when no reliable specific method of analyses was available. The concentrations were therefore not analytically verified. The substance is known for its poor water solubility and the strong tendency to adsorb onto the walls of test vessels. Therefore it was decided to perform a number of higher tier chronic invertebrate studies with analytical monitoring of the test concentrations. These higher tier tests were performed in river water to allow a PECaquatic,bulk/PNECaquatic,bulk approach for the environmental risk assessment. The long term 21d EC50 for parental mortality determined in the OECD211 test with river water (reliability 1) was used as the key value for acute toxicity for daphnia in the chemical safety assessment.
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