(2R,3S)-N-(3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitrobenzenesulfonamide hydrochloride

Guidance on Safe Use

First-aid measures

Emergency measure - Inhalation: Remove to fresh air. Give mouth to mouth resuscitation if

necessary. Seek medical attention.

Emergency measure - Eyes: Wash thoroughly with water and continue for at least 15

minutes. Seem medical attention.

Emergency measure - Skin: Remove contaminated clothing and launder before re-use.

Thoroughly wash affected areas with soap and plenty of

water. Seek medical attention.

Emergency measure - Ingestion: Wash out mouth and give water to drink. Seek medical

attention.

Fire-fighting measures

Recommended extinguishing agent: Water spray, foam, carbon dioxide, dry powder or vapourising

liquid may be used.

Product arising from burning: Products of combustion may contain oxides of carbon,

nitrogen and sulfur together with some soot.

Product determined by test: N

Protective equipment: Full protective clothing and self-contained breathing

apparatus must be worn.

Fight the fire from a safe distance or protected location.

Accidental release measures

Emergency measures in case of spillage: Evacuate personnel from immediate vicinity.

Wear appropriate personal protective equipment conforming to

the relevant national or international standards, as

mentioned in section 2.3.10.

Avoid dust formation. Absorb spillages of solutions with a

suitable inert material (eg. sand or soil). Carefully

transfer the spillage to waste containers, or use a sealed

industrial vacuum machine. Containers filled with waste

material must be labelled in the same way as the original

sustance containers. Clean the spillage area with water.

If the spillage is in an enclosed or partially enclosed

area, thoroughly ventilate and test the area before allowing

reaccess.

Dispose of waste material in accordance with local

regulations by incineration. Do not discharge to drain.

Handling and storage

Handling: The substance should be stored, handled and used under

conditions of good industrial hygiene and in conformity with

any local regulations in order to avoid exposure by skin and

eye contact, ingestion and inhalation.

Engineering controls are necessary to reduce exposure to the

substance.

When exposure cannot be prevented or adequately controlled

appropriate personal protective equipment should be worn.

Such protective equipment should conform to the appropriate

international or national standards as follows;

Chemical protective gloves to Standard prEN374

Chemical protective clothing to Standard EN368

Eye protection to Standard prEN166.

Furthermore, when respiratory protective equipment has to be

used, it must be capable of adequately controlling exposure,

be suitable for the purpose, and conform to the appropriate

international or national standards, such as a dust mask

conforming to EN149 FFP1. Use of an air suit is recommended.

Storage: Store in a dry, well-ventilated area, at or below room

temperature in clearly labelled, sealed containers.

Keep containers tightly closed when not is use.

Packaging of the substance and or preparation: Double polythene bags inside fibre board kegs.

Transport information

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Air transport (UN RTDG/ICAO/IATA)

Shipping

Special provisions / remarks

Remarks:

Transport: Avoid crushing the containers. In the event of a spillage,
observe the warning labels on the container.

SpecialProvisions

Stability and reactivity

Danger other than fire: None reported.

Chemical reaction with water: None reported.

Dust explosion: There is a potential dust explosion hazard for this organic

powder.

Dust explosion determined by test: N

Disposal considerations

Industry - Possibility of recovery/recycling: Discharge to the environment will be minimal. Recovery from

minor spillages or accidental discharge is not economically

or technically feasible, and such waste material will be

disposed of by incineration. In principle, it may be

possible to recover larger spillages of uncontaminated

material for subsequent use.

Industry - Possibility of neutralisation: The notification tests have shown that the substance is a

severe eye irritant, a skin sensitiser and is harmful by

prolonged oral expsure. No chemical treatment is practicable

to neutralise these hazardous health properties.

The dust hazard will be neuralised by appropriate storage

and handling techniques.

No chemical treatment is practicable to neutralise the

hazardous environmental properties.

Industry - Possibility of destruction: controlled discharge: There will be no discharge of the substance by landfill.

Industry - Possibility of destruction - incineration: The substance should be disposed of by incineration by

burning under controlled conditions at a licensed waste

treatment processor in accordance with local regulations.

Stack gases should be scrubbed, because noxious fumes (eg.

carbon, nitrogen and sulfur oxides) could be formed.

Industry - Possibility of destruction - water purification: The substance will not normally be discharged directly to

the sewage system or the aqueous environment. However,

adverse effects on sewage treatment systems would be

unlikely.

Public at large - Possibility of recovery/recycling: Not applicable.

Public at large - Possibility of neutralisation: Not applicable

Public at large - Possibility of destruction: controlled discharge: Not applicable.

Public at large - Possibility of destruction - incineration: Not applicable.

Public at large - Possibility of destruction - water purification: Not applicable.