Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 227-873-2 | CAS number: 6018-92-4
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
Based on the available data, DNELs for dermal and inhalation exposure were derived for workers:
The short-term dermal DNEL for local effects is derived from a LOAEL of 19 mg/cm2 observed in the acute dermal study. An assessment factor of 5 was applied, yielding a DNEL = 3.8 mg/cm2.
For the long-term dermal DNEL fos systemic effects, route-to-route extrapolation from the subchronic oral toxicity study was used. In order to take into account different absorption rates, the oral NOAEL was corrected. Applying an assessment factor of 50, the DNEL = 0.473 mg/kg bw/d.
The long-term inhalation for local effects is based on the NOAEC of a subchronic inhalation study. However, the starting point needs to be modified since exposure duration as well as activity have to be taken into account. Using an assessment factor of 12.5, the resulting DNEL = 0.010 mg/m3.
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
For the general population, DNELs do not need to be derived since Trinickel dicitrate is used as an intermediate under strictly controlled conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
