3,5,5-trimethylcyclohex-3-en-1-one

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Study well documented, meets generally accepted scientific, principles, acceptable for assessment. Data were taken from the structural analogue beta-Isophoron, CAS 78-59-1. The structural analogue differs in the location of the carbon double bound within the ring structure of the molecule, whereas the rest of the molecule is identical to CAS 471-01-2.

Data source

Reference

Reference Type:

publication

Title:

Acute toxicity of priority pollutants to water flea (Daphnia magna)

Author:

LeBlanc GA

Year:

1980

Bibliographic source:

Bull. Environ. Contam. Toxicol. 24, 684-691

Materials and methods

Principles of method if other than guideline:

Methods for acute toxicity tests with fish, macroinvertebrates, and amphibians, US EPA (1975)

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

3,5,5-trimethylcyclohex-2-enone

EC Number:

201-126-0

EC Name:

3,5,5-trimethylcyclohex-2-enone

Cas Number:

78-59-1

IUPAC Name:

3,5,5-trimethylcyclohex-2-en-1-one

Details on test material:

78 commercial substances with purities > 80 % tested

Sampling and analysis

Analytical monitoring:

no

Test organisms

Test organisms (species):

Daphnia magna

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Test conditions

Test temperature:

22 ± 1 °C

pH:

6.7 - 8.1 (no adjustment)

Dissolved oxygen:

6.5-9.1 mg/L

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

24 h

Dose descriptor:

LC50

Effect conc.:

430 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: 360-500 mg/L

Effect concentrations 2

Duration:

48 h

Dose descriptor:

NOEC

Effect conc.:

15 mg/L

Effect concentrations 3

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

120 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: 72-170 mg/L