Registration Dossier
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EC number: 204-263-4 | CAS number: 118-60-5
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 May 2020 to 09 March 2021
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Batch number of test material: 10701776
- Purity: 99.89%
- Appearance: Colorless to pale yellow, clear liquid - Key result
- Water solubility:
- 0.074 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 7.06 - <= 7.21
- Remarks on result:
- other: Standard Deviation: 0.013 mg/L
- Details on results:
- According to the test guideline five consecutive samples should not differ in concentration by
more than ±30 % and the mean values obtained from two tests with different flows should not
differ by more than 30 %. These criteria were fulfilled and therefore, the study is valid.
The R² fit of the calibration curve used was 0.9980. This reflects the linearity of the analytical
system within the calibration range of 0.0208 – 0.201 mg test item /L.
The calibration was verified by a 2nd weighing of the test item and dilution of this stock solution
into the calibration range at levels of 0.0225, 0.0419 and 0.210 mg/L. Analysis of these
solutions and evaluation against the calibration curve yielded recoveries of 80 % to 97 %
compared to the nominal values. These data show the correct preparation of the calibration
standards. - Conclusions:
- The water solubility was found to be 0.0744 ± 0.013 mg/L at 20 °C.
- Executive summary:
The determination of the water solubility of the test substance was performed according to the OECD Guideline for the Testing of Chemicals, No. 105: Water Solubility, using the column elution method with flow rates of 21 and 41 mL/h. The water solubility at 20 °C was found to be 0.0744 ± 0.013 mg/L.
Reference
Description of key information
During this study, the water solubility of the test substance was determined at 20 °C using the column elution method. The water solubility was found to be 0.0744 ± 0.013 mg/L at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 0.074 mg/L
- at the temperature of:
- 20 °C
Additional information
The determination of the water solubility of the test substance was performed according to the OECD Guideline for the Testing of Chemicals, No. 105: Water Solubility, using the column elution method with flow rates of 21 and 41 mL/h and HPLC (UV).
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