EU-IN_VITRO_MEDICAL_DEVICES-ART_3_ANX_1

In Vitro Diagnostic Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Article 3 & Annex I (Essential Requirements), Directive 98/79/EC on In Vitro Diagnostic Medical Devices, 7 December 1998

This list contains a non-exhaustive inventory of hazardous substances for purposes of essential requirements (Article 3 and Annex I) for general safety, design, manufacture and hazard communication of in vitro diagnostic medical devices. It is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list). Note that Regulation 2017/746/EU on in vitro diagnostic medical devices was published in the EU Official Journal on 5 May 2017. With few exceptions specified in Articles 112 and 113 of this Regulation, Directive 98/79/EC is repealed, and the rules pursuant to 2017/746/EU apply, from 26 May 2022.

Last updated 19 April 2024. Database contains 4821 unique substances/entries.

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Showing 1,801 - 1,900 of 4,821 results.

Substance Name	EC No.	CAS No.	EU CLP (1272/2008)	EU_BA Directive 2000/54/EC	EU REACH: List of SVHC
cyprodinil (ISO); 4-cyclopropyl-6-methyl-N-phenylpyrimidin-2-amine	601-785-8	121552-61-2	Skin Sens. 1
cyprofuram (ISO); N-(3-chlorophenyl)-N-(tetrahydro-2-oxo-3-furyl)cyclopropanecarboxamide	274-050-9	69581-33-5	Acute Tox. 3; Acute Tox. 4
Cytomegalovirus	-	-		V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
D, L-(N,N-diethyl-2-hydroxy-2-phenylacetamide) DEM	408-120-9	65197-96-8	Acute Tox. 4; Eye Dam. 1
d-carvone; (5S)-2-methyl-5- (prop-1-en-2-yl)cyclohex-2-en- 1-one	218-827-2	2244-16-8	Skin Sens. 1
D-erythro-hexanoic acid 2,4-dideoxy-3,5-O-(1-methylethylidene)-1,1-dimethylethylester; tert-butyl 2-[(4R, 6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate	432-960-5	124655-09-0	Acute Tox. 4
dalapon-sodium; sodium 2,2-dichloropropionate	204-828-5	127-20-8	Skin Irrit. 2; Eye Dam. 1
dalapon; 2,2-dichloropropionic acid	200-923-0	75-99-0	Skin Irrit. 2; Eye Dam. 1
dapsone; 4,4'-diamino diphenyl sulfone	201-248-4	80-08-0	Acute Tox. 4
dazomet (ISO);tetrahydro-3,5-dimethyl-1,3,5- thiadiazine-2-thione	208-576-7	533-74-4	Acute Tox. 4; Eye Irrit. 2
DDT (ISO); clofenotane (INN); dicophane;1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane; dichlorodiphenyltrichloroethane	200-024-3	50-29-3	Carc. 2; Acute Tox. 3; STOT RE 1
Decamethylcyclopentasiloxane; D5	208-764-9	541-02-6			yes
decanoic acid	206-376-4	334-48-5	Skin Irrit. 2; Eye Irrit. 2
decarbofuran (ISO); 2,3-dihydro-2-methylbenzofuran-7-yl methylcarbamate	-	1563-67-3	Acute Tox. 3
deltamethrin (ISO); (S)-α-cyano-3-phenoxybenzyl(1R, 3R)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate	258-256-6	52918-63-5	Acute Tox. 3
demephion-O (ISO); O, O-dimethyl O-2-methylthioethyl phosphorothioate	211-666-9	682-80-4	Acute Tox. 2; Acute Tox. 3
demephion-S (ISO); O, O-dimethyl S-2-methylthioethyl phosphorothioate	219-971-9	2587-90-8	Acute Tox. 2; Acute Tox. 3
demeton	620-378-6	8065-48-3	Acute Tox. 1; Acute Tox. 2
demeton-O (ISO); O,O-diethyl-O-2-ethylthioethyl phosphorothioate	206-053-8	298-03-3	Acute Tox. 1; Acute Tox. 2
demeton-O-methyl (ISO); O-2-ethylthioethyl O,O-dimethyl phosphorothioate	212-758-1	867-27-6	Acute Tox. 3
demeton-S (ISO); diethyl-S-2-ethylthioethyl phosphorothioate	204-801-8	126-75-0	Acute Tox. 1; Acute Tox. 2
demeton-S-methyl (ISO); S-2-ethylthioethyl dimethyl phosphorothioate	213-052-6	919-86-8	Acute Tox. 3
demeton-S-methylsulphon(ISO); S-2-ethylsulphonylethyl dimethyl phosphorothioate	241-109-5	17040-19-6	Acute Tox. 3; Acute Tox. 4
Dengue virus type 1-4	-	-		V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
desmedipham (ISO); ethyl 3-phenylcarbamoyloxyphenylcarbamate	237-198-5	13684-56-5	Repr. 2
desmetryne (ISO);6-isopropylamino-2-methylamino-4-methylthio-1,3,5- triazine	213-800-1	1014-69-3	Acute Tox. 4
di(benzothiazol-2-yl) disulphide	204-424-9	120-78-5	Skin Sens. 1
di(tetramethylammonium)(29H,31H-phthalocyanin-N29,N30,N31,N32)disulfonamide disulfonate, cuprate(2-)complex, derivates DIRECT BLUE 199	416-180-2	12222-04-7	Acute Tox. 4; STOT RE 2
Di-, tri- and tetrachlorotetradecane	950-299-5	-			yes
di-allate (ISO); S-(2,3-dichloroallyl)-N,N-diisopropylthiocarbamate	218-961-1	2303-16-4	Carc. 2; Acute Tox. 4
di-L-para-menthene PINOLENE	417-870-6	83648-84-4	Skin Irrit. 2; Skin Sens. 1
di-L-para-menthene	686-814-2	34363-01-4	Skin Irrit. 2; Skin Sens. 1
di-methylamine;di-methylamine ... %	204-697-4	124-40-3	Flam. Liq. 1; Acute Tox. 4; Skin Corr. 1B
di-methylamine;di-methylamine ... %	204-697-4	124-40-3	Flam. Gas 1; Press. Gas; Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
di-n-butyl ether; dibutyl ether	205-575-3	142-96-1	Flam. Liq. 3; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
di-n-butylamine	203-921-8	111-92-2	Flam. Liq. 3; Acute Tox. 4
di-n-octylaluminium iodide DNOAI	408-190-0	7585-14-0	Pyr. Liq. 1; Skin Corr. 1B
di-n-pentyl phthalate	205-017-9	131-18-0	Repr. 1B		yes
di-sec-butylamine	210-937-9	626-23-3	Flam. Liq. 3; Acute Tox. 4
di-tert-(C12-14)-alkylammonium 2-benzothiazolylthiosuccinate CM 26-137	406-052-4	125078-60-6	Flam. Liq. 3; Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1
di-tert-butyl peroxide	203-733-6	110-05-4	Org. Perox. E; Flam. Liq. 2; Muta. 2
dialifos (ISO); 2-chloro-1-phthalimidoethyl O,O-diethyl phosphorodithioate	233-689-3	10311-84-9	Acute Tox. 2; Acute Tox. 3
diallyl phthalate	205-016-3	131-17-9	Acute Tox. 4
dialuminium nickel tetraoxide	234-454-8	12004-35-2	Carc. 1A; STOT RE 1; Skin Sens. 1
diamminediisocyanatozinc GENIPLEX A	401-610-3	122012-52-6	Acute Tox. 4; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
diammonium 1-hydroxy-2-(4-(4-carboxyphenylazo)-2,5-dimethoxyphenylazo)-7-amino-3-naphthalenesulfonate	422-670-7	150202-11-2	Repr. 2; Acute Tox. 3; STOT RE 2
diammonium hexachloroplatinate	240-973-0	16919-58-7	Acute Tox. 3; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
diammonium nickel bis(sulfate)	239-793-5	15699-18-0	Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Acute Tox. 4; Resp. Sens. 1; Skin Sens. 1
diammonium nickel hexacyanoferrate	-	74195-78-1	Carc. 1A; STOT RE 1; Resp. Sens. 1; Skin Sens. 1
diammonium peroxodisulphate; ammonium persulphate	231-786-5	7727-54-0	Ox. Sol. 3; Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1; Skin Sens. 1
diammonium tetrachloroplatinate	237-499-1	13820-41-2	Acute Tox. 3; Skin Irrit. 2; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
diarsenic pentaoxide; arsenic pentoxide; arsenic oxide	215-116-9	1303-28-2	Carc. 1A; Acute Tox. 3		yes
diarsenic trioxide; arsenic trioxide	215-481-4	1327-53-3	Carc. 1A; Acute Tox. 2; Skin Corr. 1B		yes
diazinon (ISO); O,O-diethyl O-2-isopropyl-6-methylpyrimidin-4-yl phosphorothioate	206-373-8	333-41-5	Acute Tox. 4
diazomethane	206-382-7	334-88-3	Carc. 1B
dibenz[a,h]anthracene	200-181-8	53-70-3	Carc. 1B
dibenzo[b,def]chrysene; dibenzo[a,h]pyrene	205-878-0	189-64-0	Carc. 1B; Muta. 2
dibenzo[def,p]chrysene; dibenzo[a,l]pyrene	205-886-4	191-30-0	Carc. 1B; Muta. 2
dibenzoyl peroxide; benzoyl peroxide	202-327-6	94-36-0	Org. Perox. B; Eye Irrit. 2; Skin Sens. 1
dibenzylphenylsulfonium hexafluoroantimonate ZK RT 1507	417-760-8	134164-24-2	STOT RE 1; Acute Tox. 4; Eye Dam. 1; Skin Sens. 1
diboron trioxide	215-125-8	1303-86-2	Repr. 1B		yes
dibromomethane	200-824-2	74-95-3	Acute Tox. 4
dibutyl phthalate; DBP	201-557-4	84-74-2	Repr. 1B		yes
dibutyl-3-(4-(5-ammonio-2-butyl)benzofuran-3-yl)carbonyl)phenoxy)propyl ammonium oxalate; (5-amino-2-butylbenzofuran-3-yl) [4-(3-dibutylaminopropoxy)phenyl]methanone, dioxalate AMINODARONE OXALATE; SR33580A	448-700-9	500791-70-8	STOT RE 2; Eye Dam. 1; Skin Sens. 1
dibutylbis(pentane-2,4-dionato-O,O')tin	245-152-0	22673-19-4	Repr. 1B; STOT RE 1		yes
dibutyltin dichloride; (DBTC)	211-670-0	683-18-1	Muta. 2; Repr. 1B; Acute Tox. 2; Acute Tox. 3; Acute Tox. 4; STOT RE 1; Skin Corr. 1B		yes
dibutyltin dilaurate; dibutyl[bis(dodecanoyloxy)] stannane	201-039-8	77-58-7	Muta. 2; Repr. 1B; STOT RE 1
dibutyltin hydrogen borate DBB	401-040-5	75113-37-0	Repr. 1B; Muta. 2; STOT RE 1; Acute Tox. 4; Eye Dam. 1; Skin Sens. 1
dicamba (ISO); 2,5-dichloro-6-methoxybenzoic acid; 3,6-dichloro-2-methoxybenzoic acid	217-635-6	1918-00-9	Acute Tox. 4; Eye Dam. 1
dichlobenil (ISO); 2,6-dichlorobenzonitrile	214-787-5	1194-65-6	Acute Tox. 4
dichlofenthion (ISO); O—2,4-dichlorophenyl O,O-diethyl phosphorothioate	202-564-5	97-17-6	Acute Tox. 4
dichlofluanid (ISO); N-dichlorofluoromethylthio-N',N'-dimethyl-N-phenylsulfamide	214-118-7	1085-98-9	Acute Tox. 4; Eye Irrit. 2; Skin Sens. 1
dichlone (ISO); 2,3-dichloro-1,4-naphthoquinone	204-210-5	117-80-6	Acute Tox. 4; Eye Irrit. 2; Skin Irrit. 2
dichloro-(3-(3-chloro-4-fluorophenyl)propyl)methylsilane SILAN DCS	407-180-3	770722-36-6	Skin Corr. 1A
dichloro-1,3,5-triazinetrione; dichloroisocyanuric acid	220-487-5	2782-57-2	Ox. Sol. 2; Acute Tox. 4; Eye Irrit. 2; STOT SE 3
dichloroacetic acid	201-207-0	79-43-6	Skin Corr. 1A
dichloroacetyl chloride	201-199-9	79-36-7	Skin Corr. 1A
dichloroacetylene	620-404-6	7572-29-4	Unst. Expl.; Carc. 2; STOT RE 2
dichlorodioctyl stannane	222-583-2	3542-36-7	Repr. 1B; Acute Tox. 2; STOT RE 1
dichloromethane; methylene chloride	200-838-9	75-09-2	Carc. 2
dichlorophen (ISO)	202-567-1	97-23-4	Acute Tox. 4; Eye Irrit. 2
dichlorprop (ISO); 2-(2,4-dichlorophenoxy)propionic acid	204-390-5	120-36-5	Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1
dichlorprop-P (ISO); (+)-R-2-(2,4-dichlorophenoxy)propionic acid D-2,4-DP; DICHLORPROP-P; DUPLOSAN DP-ACID	403-980-1	15165-67-0	Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
dichlorvos (ISO); 2,2-dichlorovinyl dimethyl phosphate	200-547-7	62-73-7	Acute Tox. 2; Acute Tox. 3; Skin Sens. 1
Dichromic acid	236-881-5	13530-68-2			yes
dichromium tris(chromate); chromium III chromate; chromic chromate	246-356-2	24613-89-6	Ox. Sol. 1; Carc. 1B; Skin Corr. 1A; Skin Sens. 1		yes
diclobutrazole (ISO);(R, R)-(±)-β-[(2,4-dichlorop henyl)methyl]-α-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol; (2RS, 3RS)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2- (1H—1,2,4-triazol-1yl)pentan-3-ol	620-436-0	75736-33-3	Eye Irrit. 2
diclofop-methyl (ISO)methyl 2-(4-(2,4-dichlorophenoxy)phenoxy)propionate; methyl (RS)-2-[4-(2,4-dichlorophenoxy)phenoxy]propionate	257-141-8	51338-27-3	Acute Tox. 4; Skin Sens. 1
dicofol (ISO); 2,2,2-trichloro-1,1-bis(4-chlorophenyl)ethanol	204-082-0	115-32-2	Acute Tox. 4; Skin Irrit. 2; Skin Sens. 1
dicopper chloride trihydroxide	215-572-9	1332-65-6	Acute Tox. 4; Acute Tox. 3
dicopper oxide; copper (I) oxide	215-270-7	1317-39-1	Acute Tox. 4; Eye Dam. 1
dicoumarol; 4,4'-dihydroxy-3,3'-methylenebis(2H-chromen-2-one)	200-632-9	66-76-2	STOT RE 1; Acute Tox. 4
dicrotophos (ISO); (Z)-2-dimethylcarbamoyl-1-methylvinyl dimethyl phosphate	205-494-3	141-66-2	Acute Tox. 2; Acute Tox. 3
dicyclohexyl phthalate	201-545-9	84-61-7	Repr. 1B; Skin Sens. 1		yes
dicyclohexylamine	202-980-7	101-83-7	Acute Tox. 4; Skin Corr. 1B
dicyclohexylammonium nitrite	221-515-9	3129-91-7	Acute Tox. 4
dicyclohexylcarbodiimide	208-704-1	538-75-0	Acute Tox. 3; Acute Tox. 4; Eye Dam. 1; Skin Sens. 1
dicyclopentyldimethoxysilane DCPMS; DYNASYLAN 9415; EURENOR 5023; SAN-30; WACKER SILAN CP2-DIMETHOXY; Z-6228	404-370-8	126990-35-0	Skin Irrit. 2; Eye Dam. 1
didecyldimethylammonium chloride	230-525-2	7173-51-5	Acute Tox. 4; Skin Corr. 1B
dieldrin (ISO)	200-484-5	60-57-1	Carc. 2; Acute Tox. 1; Acute Tox. 3; STOT RE 1

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EU-IN_VITRO_MEDICAL_DEVICES-ART_3_ANX_1

EU-IN_VITRO_MEDICAL_DEVICES-ART_3_ANX_1

In Vitro Diagnostic Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Article 3 & Annex I (Essential Requirements), Directive 98/79/EC on In Vitro Diagnostic Medical Devices, 7 December 1998

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Last updated 19 April 2024. Database contains 4821 unique substances/entries.

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