Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
206-992-3
CAS no.:
420-04-2
Index number:
615-013-00-2
Molecular formula:
CH2N2
SMILES:
NC#N
InChI:
InChI=1S/CH2N2/c2-1-3/h2H2
Type of substance:
Mono constituent substance
Origin:
Organic, Inorganic
Registered compositions:
5
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP10) approved by the European Union, this substance is toxic if swallowed, is toxic in contact with skin, causes severe skin burns and eye damage, causes serious eye damage, is suspected of causing cancer, is suspected of damaging fertility and the unborn child, may cause damage to organs through prolonged or repeated exposure, is harmful to aquatic life with long lasting effects and may cause an allergic skin reaction.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is suspected of damaging fertility or the unborn child.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance causes skin irritation.

Breakdown of all 229 C&L notifications submitted to ECHA

Acute Tox. 3 H301 Harmonised Classification
Skin Sens. 1 H317 Harmonised Classification
Acute Tox. 3 H311 Harmonised Classification
Repr. 2 H361fd Harmonised Classification
STOT RE 2 H373 Harmonised Classification
Aquatic Chronic 3 H412 Harmonised Classification
Eye Dam. 1 H318 Harmonised Classification
Carc. 2 H351 Harmonised Classification
Skin Corr. 1A H314
Skin Corr. 1 H314 Harmonised Classification
Eye Irrit. 2 H319
Skin Irrit. 2 H315
Acute Tox. 4 H312
Skin Corr. 1B H314
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • C
Suspected to be Carcinogenic (Harmonised C&L).
  • R
Suspected to be Toxic to Reproduction (Harmonised C&L).
  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (100% of REACH registrations).
  • ED
Under assessment as Endocrine Disrupting (ED list).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 2 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
This substance is approved for use as a Biocidal Active Substance
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
This substance is subject to the Prior Informed Consent regulation and to export notification procedure from 01-Mar-2014
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 tonnes per annum.

This substance is used in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following activities or processes at workplace: mixing in open batch processes, transfer of chemicals at dedicated facilities and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: plant protection products.

This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, transfer of chemicals at dedicated facilities, transfer of substance into small containers, laboratory work and closed processes with no likelihood of exposure.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: closed, continuous processes with occasional controlled exposure, transfer of chemicals at dedicated facilities, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: avoid release to the environment; do not breathe the dust, fume, gas, mist, vapours or spray; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. If swallowed: rinse mouth. Do not induce vomiting. Immediately call a poison center or doctor/physician. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.

Storage statements

Store this substance locked up.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Alzchem Trostberg GmbH, Dr.-Albert-Frank-Straße 32 83308 Trostberg Bayern Germany
  • Schirm GmbH, Geschwister-Scholl-Strasse 127 D-39218 Schönebeck Germany
  • Arcerion GmbH, Gabrielenstr. 15 80636 München Germany

Substance names and other identifiers

Cyanamide
EC Inventory, PIC, REACH pre-registration, Other, Cosmetic Products Regulation, Annex II - Prohibited Substances, Occupational Exposure Limits - 2nd list - Indicative OELVs, Annexes II, III, IV, VII - Defined & Temporary Maximum Residue Levels, Statistics on Pesticides Regulation - Annex III Harmonized C&L, PIC Annex I, PIC Import notification,
Cyanamide
PIC, Biocidal active substances, REACH pre-registration, Other, Cosmetic Products Regulation, Annex II - Prohibited Substances, Occupational Exposure Limits - 2nd list - Indicative OELVs, Annexes II, III, IV, VII - Defined & Temporary Maximum Residue Levels, Statistics on Pesticides Regulation - Annex III Harmonized C&L, PIC Annex I, PIC Import notification,
cyanamide carbamonitril
C&L Inventory
cyanamide; carbanonitril
FCM Active and Intelligent Materials - CMRs not allowed for use, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
Cianamid (hr)
Biocidal active substances
Cianamid (sl)
Biocidal active substances
cianamid karbamonitril (sl)
C&L Inventory
Cianamida (es)
Biocidal active substances
Cianamida (pt)
Biocidal active substances
cianamida carbanonitril (es)
C&L Inventory
cianamida carbanonitril (pt)
C&L Inventory
cianamida carbanonitril (ro)
C&L Inventory
Cianamidas (lt)
Biocidal active substances
cianamidas karbamonitrilas (lt)
C&L Inventory
Cianamidă (ro)
Biocidal active substances
Cianammide (it)
Biocidal active substances
cianammide carbanonitril (it)
C&L Inventory
Ciánamid (hu)
Biocidal active substances
ciánamid karbanonitril (hu)
C&L Inventory
Ciānamīds (lv)
Biocidal active substances
ciānamīds karbanonitrils (lv)
C&L Inventory
Cyaanamide (nl)
Biocidal active substances
cyaanamide carbanonitril (nl)
C&L Inventory
cyanamid (da)
C&L Inventory, Biocidal active substances
Cyanamid (de)
C&L Inventory, Biocidal active substances
Cyanamid (sv)
C&L Inventory, Biocidal active substances
cyanamid carbanonitril (da)
C&L Inventory
Cyanamid Carbanonitril (de)
C&L Inventory
cyanamid karbanonitril (no)
C&L Inventory
Cyanamide (fr)
Biocidal active substances
Cyanamide (no)
Biocidal active substances
cyanamide carbanonitril (fr)
C&L Inventory
cyjanamid cyjanoamid (pl)
C&L Inventory
Cyjanoamid (pl)
Biocidal active substances
karbamonitril (cs)
Biocidal active substances
kyanamid karbonitril (cs)
C&L Inventory
kyánamid (sk)
Biocidal active substances
kyánamid karbanonitril (sk)
C&L Inventory
Syanamidi (fi)
Biocidal active substances
Syanamidi Karbanonitriili (fi)
C&L Inventory
Tsüaanamiid (et)
Biocidal active substances
tsüaanamiid karbonitriil (et)
C&L Inventory
Ċjanammid (mt)
Biocidal active substances
Κυαναμίδιο (el)
Biocidal active substances
κυαναμίδιο carbanonitril (el)
C&L Inventory
Цианамид (bg)
Biocidal active substances
цианамид карбанонитрил (bg)
C&L Inventory
aminoformonitrile
C&L Inventory, Other
carbanonitril
C&L Inventory
carbodiimide
C&L Inventory
Cyanamide
C&L Inventory, Registration dossier, Other
Cyanamide
C&L Inventory, Registration dossier, Other
Amidocyanogen
Registration dossier
Carbamic acid nitrile
Registration dossier
Carbamonitrile
Registration dossier
Carbimide
Registration dossier
Carbodiimide
Registration dossier
Cyanamid
Registration dossier
Cyanamide
Registration dossier
Cyanoamine
Registration dossier
Cyanogen amide
Registration dossier
Cyanogen nitride
Registration dossier
Hydrogen cyanamide
Registration dossier
N-Cyanoamine
Registration dossier
2853 90 90
CN Code
PIC, Other
2853 90 90
CN number
PIC
32729-71-8
CAS number
Other
420-04-2
CAS number
EC Inventory, C&L Inventory, PIC, Biocidal active substances, Registration dossier, REACH pre-registration, Other, FCM Active and Intelligent Materials - CMRs not allowed for use, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Occupational Exposure Limits - 2nd list - Indicative OELVs, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Annexes II, III, IV, VII - Defined & Temporary Maximum Residue Levels, Statistics on Pesticides Regulation - Annex III Harmonized C&L, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work, PIC Annex I, PIC Import notification,
615-013-00-2
Index number
C&L Inventory
65931-45-5
CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Solid: bulk (100%) [1]
C Odour
Odourless (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)
Form
Solid: bulk (100%)
Colour
colourless (100%)

Melting/freezing point

Study results
  • 1 study submitted
  • 1 study processed
R Melting / freezing point
46.1 °C @ 101.325 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
46.1 °C

Boiling point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 1 study submitted
  • 1 study processed
R Relative density
1.23 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
1.23

Vapour pressure

Study results
  • 1 study submitted
  • 1 study processed
R Vapour pressure
0.51 - 1 Pa @ 20 - 25 °C [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
1 Pa @ 24.95 °C

Partition coefficient

Study results
  • 1 study submitted
  • 1 study processed
R Pow
0.19 @ 20 °C and pH 6.8 [1]
R Log Pow
-0.72 @ 20 °C and pH 6.8 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
-0.72 @ 20 °C

Water solubility

Study results
  • 1 study submitted
  • 1 study processed
R Water solubility (mass/vol.)
530 - 800 g/L @ 20 °C and pH 3.8 - 11 [3]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
800 g/L @ 20 °C

Solubility in organic solvents / fat solubility

Study results
  • 1 study submitted
  • 1 study processed
R Acetone
210 g/L @ 20 °C [1]
R Ethyl acetate
210 g/L @ 20 °C [1]
R Isopropanol
210 g/L @ 20 °C [1]
R Methanol
210 g/L @ 20 °C [1]
R Toluene
670 mg/L @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 3 studies submitted
  • 1 study processed
R Surface tension
72.86 mN/m @ 1 g/L and 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Surface tension at 20 °C
72.9 mN/m @ 1 000 mg/L

Flash point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 6 studies submitted
  • 1 study processed
C Interpretation of results
Not classified based on GHS criteria (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified 3
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Not classified (100%)

Explosiveness

Study results
  • 3 studies submitted
  • 1 study processed
C Interpretation of results
GHS criteria not met (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
Non oxidising (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 1 study submitted
  • 1 study processed
C Dissociating properties
No (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 1 study submitted
  • 1 study processed
R Dissipation Half-life (DT50)
28.9 - 139 days [4]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in water
38.5 days

Phototransformation in soil

Study results
  • 2 studies submitted
  • 1 study processed
R Dissipation Half-life (DT50)
2 - 2.4 h [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in soil
2.4 h

Biodegradation in water - screening tests

Study results
  • 2 studies submitted
  • 1 study processed
C Interpretation of results
Under test conditions no biodegradation observed (100%) [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)
Type of water
Freshwater (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in freshwater
4.3 days @ 19.85 °C

Biodegradation in soil

Study results
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 5 2 1
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in soil
18.72 h @ 20 °C

Bioaccumulation: aquatic / sediment

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Study results
  • 1 study submitted
  • 1 study processed
R H - (pressure) m³/mol
0 Pa m³/mol @ 20 °C and 100 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 10 µg/L (1)
Intermittent releases (freshwater) 32 µg/L (1)
Marine water 1 µg/L (1)
Intermittent releases (marine water) 3 µg/L (1)
Sewage treatment plant (STP) 88 mg/L (1)
Sediment (freshwater) 40 µg/kg sediment dw (1)
Sediment (marine water) 4 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 151.5 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning 500 µg/kg food (1)

Short–term toxicity to fish

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
LC50 (4 days) 43.1 mg/L [1]
NOEC (4 days) 30.6 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (21 days) 3.7 mg/L [1]
LC50 (21 days) 11.8 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (48 h) 3.2 mg/L [1]
LC50 (48 h) 4.3 mg/L [1]
NOEC (48 h) 1.6 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (21 days) 104.4 µg/L [1]
EC50 (21 days) 410 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
EC50 (4 days) 6.7 - 16.6 mg/L [2]
EC50 (72 h) 12.6 - 28.8 mg/L [2]
NOEC (4 days) 2.6 mg/L [2]
NOEC (72 h) 5 mg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
14.7 mg/L
EC10 or NOEC for freshwater algae
2.6 mg/L

Toxicity to aquatic plants other than algae

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (7 days) 2.33 - 5.61 mg/L [3]
NOEC (7 days) 500 µg/L [3]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater plants
5.61 mg/L
EC10 or NOEC for freshwater plants
500 µg/L

Toxicity to microorganisms

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (19 h) 283 mg/L [1]
NOEC (19 h) 88 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
283 mg/L
EC10 or NOEC for microorganisms
88 mg/L

Sediment toxicity

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (28 days) 6.64 - 18.39 mg/L [2]
LOEC (28 days) 11.24 - 30.66 mg/L [2]
EC50 (28 days) 28.97 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Study results
  • 4 studies submitted
  • 3 studies processed
P/RResults
NOEC (21 days) 1.2 - 6 mg/L [3]
NOEC (72 h) 30 mg/L [1]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No summary exists for this scientific endpoint

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
NOEC (14 days) 500 mg/kg soil dw [1]
LOEC (14 days) 1 g/kg soil dw [1]
LC50 (14 days) 111.3 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
111.3 mg/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 16 studies submitted
  • 3 studies processed
P/RResults
EC10 (28 days) 1.515 - 4.2 mg/kg soil dw [2]
EC50 (28 days) 19.1 - 22.662 mg/kg soil dw [2]
LC100 (72 h) 258 µg per animal [1]
LC50 (28 days) 53.2 mg/kg soil dw [1]
LC50 (72 h) 51.6 µg per animal [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 13
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
1.515 mg/kg soil dw

Toxicity to terrestrial plants

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
NOEC (39 days) 50 - 100 mg/kg soil dw [5]
NOEC (28 days) 50 - 100 mg/kg soil dw [5]
NOEC (14 days) 50 - 100 mg/kg soil dw [3]
EC50 (14 days) 870 g/ha [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
100 mg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
NOEC (5.133 months) 152 mg/kg bw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
5 g/kg food
Long-term EC10 / LC10 / NOEC
152 mg/kg food

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 350 µg/m³ repeated dose toxicity
Acute /short term: (No hazard identified) -
Local Effects
Long-term: (Medium hazard (no threshold derived)) -
Acute /short term: (Medium hazard (no threshold derived)) -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 670 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 2.01 mg/kg bw/day acute toxicity
Local Effects
Long-term: (High hazard (no threshold derived)) -
Acute /short term: (High hazard (no threshold derived)) -
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 125 µg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: (Medium hazard (no threshold derived)) -
Acute /short term: (Medium hazard (no threshold derived)) -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 240 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 720 µg/kg bw/day acute toxicity
Local Effects
Long-term: (High hazard (no threshold derived)) -
Acute /short term: (High hazard (no threshold derived)) -
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 72 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 216 µg/kg bw/day repeated dose toxicity
EYE Exposure
Medium hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 2 studies submitted
  • 1 study processed
P/RResults
LD50 142 mg/kg bw (rat) [1]
M/CInterpretations of results
Category 3 based on GHS criteria [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 1 study submitted
  • 1 study processed
P/RResults
LC50 (4 h) 1 mg/L air (rat) [1]
M/CInterpretations of results
GHS criteria not met [1]

inhalation
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 1 study submitted
  • 1 study processed
P/RResults
LD50 742 - 901 mg/kg bw (rabbit) [3]
M/CInterpretations of results
Category 3 based on GHS criteria [1]

dermal
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 142 mg/kg bw
Inhalation route:
No adverse effect observed LC50 1 mg/L air
Dermal route:
Adverse effect observed LD50 848 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 6
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (corrosive)
Eye
Adverse effect observed (irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
Adverse effect observed (sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 7 studies submitted
  • 3 studies processed
P/RResults
NOAEL (rat): 1.5 - 5 mg/kg bw/day [2]
NOAEL (dog): 1 mg/kg bw/day [1]
LOAEL (rat): 4.5 - 5 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 3
Supporting study 3 1
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 1 study submitted
  • 1 study processed
P/RResults
NOAEL (rat): 260 mg/m³ air [1]

Study data: inhalation
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 1 study processed
P/RResults
NOAEL (rabbit): 25 mg/kg bw/day [1]

Study data: dermal
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed NOAEL 1 mg/kg bw/day (chronic, dog)
Dermal route - systemic effects:
Adverse effect observed NOAEL 25 mg/kg bw/day (subacute, rabbit)
Inhalation route - systemic effects:
Adverse effect observed NOAEC 262.9 µg/m³ (subacute, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 5
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 4
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed NOAEL 8.4 mg/kg bw/day (subacute, mouse)

Toxicity to reproduction

Study results
Study data: reproduction
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study 4 1
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Oral route:
Adverse effect observed NOAEL 3.75 mg/kg bw/day (subchronic, rat)
Effect on developmental toxicity
Oral route:
Adverse effect observed NOAEL 3 mg/kg bw/day (subchronic, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant