Registration Dossier
Registration Dossier
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EC number: 846-828-3 | CAS number: 1872341-39-3
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (1,2-dimethylpropyl)-5-methyl-pyrazole-4-carboxylic acid
- EC Number:
- 846-828-3
- Cas Number:
- 1872341-39-3
- Molecular formula:
- C10H16N2O2
- IUPAC Name:
- (1,2-dimethylpropyl)-5-methyl-pyrazole-4-carboxylic acid
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- - Source and lot/batch No.of test material:
L2018-005
- Expiration date of the lot/batch: 01 Apr 2020
- Purity: 99.8 %
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Analysis of the test media samples was conducted on fresh media at 0 hours and on
corresponding old media at 48 hours
Test solutions
- Vehicle:
- no
- Details on test solutions:
- The definitive test was conducted at the nominal test substance concentration of 100 mg/L. A control treatment was also included in the test.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna Straus, Clone V, was used as the test organism. The animals are continuously
bred in the laboratory and were originally purchased in a healthy condition from the Federal
Environment Agency in Berlin/Germany. Freshly hatched daphnids less than 24 hours old and not first brood progeny were used for the
test.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 19.1-19.9°C
- pH:
- 7.04 - 7.85
- Dissolved oxygen:
- >=6.4 mg/l
- Nominal and measured concentrations:
- The measured content of test item was 95 % of nominal in the fresh sample. In the aged sample
the measured content was 105 % of nominal. Therefore toxicological endpoints were evaluated
using the nominal concentrations of the test item.
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
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