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EC number: 203-770-8
CAS number: 110-46-3
was induced on THP-1 cells byISOAMYL NITRITE. According to this
cytotoxic profile, CV75 value of 160 µg/mL could be determined.However,
no cytotoxicity was observed for the two highest concentrations tested.In
the activation tests, therefore, the doses-range was chosen between 7.81
and 1000 µg/mLto
cover a cytotoxic profile until 50% of dead cells.
reproducible "increase" of the CD54/CD86 expression compared with the
negative control for at least three and two dose-levels respectively of ISOAMYL
a dose-response relationship was noticed for CD54/CD86 markers with an
increase of 2.37 to 12.15 and 1.68 to 2.69 fold of expression compared
to the negative control, respectively.
these results, the test item “ISOAMYL
anin vitrosensitizing potential with a Minimum Induction
Threshold (MIT) of 85 µg/mL under the conditions used during this study.
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