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EC number: 444-340-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 29, 2002 - June 07, 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study under GLP compliance with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
Test material
- Reference substance name:
- MV31 Kaliumsalz
- IUPAC Name:
- MV31 Kaliumsalz
- Details on test material:
- - Name of test material (as cited in study report): MV31 Kaliumsalz
- Substance type: Single component
- Physical state: grey globular substance
- Storage condition of test material: dry and room temperature
Constituent 1
- Radiolabelling:
- no
Study design
HPLC method
- Details on study design: HPLC method:
- The Koc of MV31 K salt was determined based on the correlation between the retention of a substance on a reversed phase column packed with a commercially available cyanopropyl solid phase containing lipophilic and polar moieties and the adsorption coefficient Koc.
EQUIPMENT:
- Apparatus: HPLC pump G1311 A, Autosampler G1313A, column oven G1316A,
- Type, material and dimension of analytical (guard) column: stationary phase: LiChrospher 100 CN 5 µm by Duratec (18904-02); material: stainless steel; dimension: 125 mm x 4.6 mm; Column temperature: 20°C;
- Detection system: UV/VIS detector G1314A by Agilent. Detection wavelength at 210 nm (dead time marker and test substance), 220 nm (calibration substances without Direct Red), 395 nm (direct Red).
MOBILE PHASES:
- Type: acetonitrile/buffer pH 8.0 25:75 (v/v), isocratic elution;
- Flow rate: 0.8 ml/min;
- Injection volume: 10 µl (dead time marker and calibration substances without Direct Red), 25 µl (test substance), 100 µl (direct Red).
DETERMINATION OF DEAD TIME: The dead time marker was Uracil dissolved in acetonitrile/distilled water (50:50) and injected twice. The mean dead time of the test system was 2.05 minutes.
Calibration Substances:
- Identity: Benzamide, Acetanilide, Aniline, Monuron; 3,5-Dinitrobenzamide, Triadimenol; Linuron; terbutryn, Naphthalene, Direct Red 81. The Calibration substances (without Direct Red) were dissolved in acetonitrile and diluted 0.1 to 1 in the mobile phase and injected as single standard twice. Direct Red was dissolved in distilled water and diluted 0.1 to 1 in the mobile phase and injected as single standard twice. It is notable that the calibration substances are aromatic compounds and/or pesticides. The calibration substances are approved for use in the method, but bear little or no structural similarity to the test substance. This is a limitation of the test guideline.
DETERMINATION OF RETENTION TIMES
- Quantity of dead time marker: 2.72 µg
- Quantity of test substance introduced in the column: 111.13 µg
- Quantity of calibration substances: 0.71 - 7.42 µg
REPETITIONS
- Number of determinations: Two (duplicate) injections
EVALUATION
- Calculation of capacity factors k': k' = (Tr - T0) / T0, where: Tr = retention time;
T0 = mean column dead time (Uracil peak);
- Calculation of retention times: The test substance was dissolved in distilled water and diluted 0.5 to 1 with acetonitrile/buffer pH 8.0 50:50 (v/v) and injected twice. Mean retention times were taken for the unretained and test substance retention times only. Retention times for the duplicated injections of the calibration substance peaks were used to generate the regression curve.
- Determination of the log Koc value: Linear regression according to calibration curve of the log k of the reference substances as function of log Koc
log Koc = a +b x logk
Results and discussion
Adsorption coefficient
- Type:
- log Koc
- Value:
- 1.83
- Temp.:
- 20 °C
- Remarks on result:
- other: RSD% = 1.4
Results: HPLC method
- Details on results (HPLC method):
- - Retention times of calibration substances used for calibration: 3.19 - 18.18 min (See table 1)
- Details of fitted regression line (log k' vs. log Koc):
1st measurement: a = 1.3591, b =1.5495, r² = 0.856,
2nd measurement: a = 1.3616, b = 1.549, , r² = 0.8547,
MV31 K salt had retention time of 5.45 minutes and 5.25 minutes for the duplicate measurements. The Log Koc were 1.85 and 1.81, respectively. Average Log Koc was 1.83, with RSD% = 1.4%
Any other information on results incl. tables
Table 1. Koc determination of MV 31 K Salt
Substance |
Tr,1 [min] |
Tr,2 [min] |
mean Tr (n=2) |
K |
Log K |
log Koc |
Uracil (t0) |
2.04 |
2.05 |
2.05 |
|
|
|
Measurement 1 |
|
|||||
Benzamide |
3.19 |
|
|
0.56 |
-0.25 |
1 |
Acetanilide |
4.09 |
|
|
1 |
0 |
1.25 |
Aniline |
4.21 |
|
|
1.06 |
0.02 |
2.07 |
Monuron |
6.71 |
|
|
2.28 |
0.36 |
2.21 |
3,5-Dinitrobenzamide |
5.06(1) |
|
|
1.47 |
0.17 |
2.31 |
Triadimenol |
13.11 |
|
|
5.41 |
0.73 |
2.4 |
Linuron |
15.84 |
|
|
6.74 |
0.83 |
2.59 |
Terbutryn |
13.99 |
|
|
5.84 |
0.77 |
2.68 |
Naphthalene |
18.18 |
|
|
7.88 |
0.9 |
2.75 |
Direct Red 81 |
3.91(1) |
|
|
0.91 |
-0.04 |
3.43 |
|
Log Koc = 1.5495 + 1.3591 log K (r² = 0.856) |
|||||
MV 31 K salt |
5.45 |
|
|
1.66 |
0.22 |
1.85 |
|
||||||
Measurement 2 |
|
|||||
Benzamide |
|
3.19 |
|
0.56 |
-0.25 |
1 |
Acetanilide |
|
4.09 |
|
1 |
0 |
1.25 |
Aniline |
|
4.2 |
|
1.05 |
0.02 |
2.07 |
Monuron |
|
6.71 |
|
2.28 |
0.36 |
2.21 |
3,5-Dinitrobenzamide |
|
5.04 |
|
1.46 |
0.16 |
2.31 |
Triadimenol |
|
13.1 |
|
5.4 |
0.73 |
2.4 |
Linuron |
|
15.78 |
|
6.71 |
0.83 |
2.59 |
Terbutryn |
|
13.96 |
|
5.82 |
0.77 |
2.68 |
Naphthalene |
|
18.1 |
|
7.85 |
0.89 |
2.75 |
Direct Red 81 |
|
3.78 |
|
0.84 |
-0.07 |
3.43 |
|
Log Koc = 1.549 + 1.3616 log K (r² = 0.8547) |
|||||
MV 31 K salt |
|
5.25 |
|
1.57 |
0.2 |
1.81 |
(1)Not used for calculation
Applicant's summary and conclusion
- Conclusions:
- Log Koc value of test substance was 1.83.
- Executive summary:
Log Koc value of MV 31 K salt was assessed according to OECD Guideline TG121 "Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using HPLC". Under the analytical conditions used, the test substance had a log Koc value of 1.83 with RSD% of 1.4%.
The study was conducted according to internationally accepted test guidelines and under GLP compliance. The calibration substances are approved for use in the method, but bear little or no structural similarity to the test substance. Therefore, this study is considered as reliable with restrictions.
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