Registration Dossier
Registration Dossier
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EC number: 624-182-1 | CAS number: 4187-38-6
Endpoint summary
Administrative data
Description of key information
Rac-1-(3-Methoxyphenyl)ethylamine (read across, CAS 62409-13-6) showed a corrosive potential to the skin (OECD 431) and to the eyes (HET-CAM Test).
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- See chap. 13 read across justification
- Reason / purpose for cross-reference:
- read-across source
- Irritation / corrosion parameter:
- other: cell viability
- Value:
- ca. 92
- Remarks on result:
- other: Basis: mean. Time point: 3 min. Reversibility: other: not applicable. Remarks: score = viability [% of negative control]. (migrated information)
- Irritation / corrosion parameter:
- other: cell viability
- Value:
- ca. 9
- Remarks on result:
- other: Basis: mean. Time point: 1 h. Reversibility: other: not applicable. Remarks: score = viability [% of negative control]. (migrated information)
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- See chap. 13 read across justification
- Reason / purpose for cross-reference:
- read-across source
- Remarks on result:
- other: The undiluted test substance caused severe intravascular as well as extravascular coagulation and moderate haemorrhagia in all eggs within 9 – 12 seconds after application.
- Remarks on result:
- other: The 10% test-substance solution in olive oil Ph.Eur./DAB caused moderate intravascular coagulation in all eggs after 49 – 85 seconds and moderate haemorrhagia in all eggs within 11 – 17 seconds.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Additional information
Skin corrosion
Based on the results it was concluded, that rac-1-(3-Methoxyphenyl)ethylamine (read across, CAS 62409-13-6) shows a corrosive potential in the EpiDerm skin corrosivity test. The test method does not yet allow for the differentiation of severity of the effect. The results however indicate moderate corrosivity. For final assignment of a risk phrase at present, further evidence or results from an in vivo study would be needed. [BASF, 2007]
Eye irritation
Based on the results it was concluded, that
rac-1-(3-Methoxyphenyl)ethylamine (read across, CAS 62409-13-6) caused
serious eye damage in the HET-CAM Test under the test conditions. [BASF,
2007]
Justification for classification or non-classification
Based on the available data for rac-1-(3-Methoxyphenyl)ethylamine (read across, CAS 62409-13-6) (R)-1-(4-Methylphenyl)ethylamine is subject to C&L:
according to Regulation 1272/2008/EC: skin corrosion cat. 1B, H314
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