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Description of key information

The octanol-water partition coefficient (LogKow or LogP) was estimated by using three

different predictors: ACD/Percepta LogP Classic, ACD/Percepta LogP GALAS and KOWWIN predictors.

Key value for chemical safety assessment

Log Kow (Log Pow):
2.42

Additional information

Partition coefficient n-octanol/water predictions:

ACD/logP Classic

ACD/logP GALAS

KOWWIN LogP

WoE LogP prediction

2.29 ±0.54

(Not reliable)

2.51

(High reliable)

2.28

(Moderate reliable)

2.42

(High reliable)

In the weight of evidence assessment only reliable predictions are to be taken into account. ACD/Percepta LogP Classic was not included in the weight of evidence assessment since it did not provide a reliable prediction. Thus, the weight of evidence prediction was computed as the weighted mean among ACD/LogP GALAS and EPI Suite/KOWWIN, where ACD/LogP GALAS prediction was weighted more (0.6) than EPI Suite/KOWWIN (0.4) because of its higher reliability.For thePipamperonethe weight of evidence assessment led to a high reliable LogKow prediction of 2.42.