Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-375-9 | CAS number: 3081-14-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- other: acute oral toxicity study
- GLP compliance:
- no
- Test type:
- other: acute oral toxicity study
Test material
- Reference substance name:
- N,N'-bis(1,4-dimethylpentyl)-p-phenylenediamine
- EC Number:
- 221-375-9
- EC Name:
- N,N'-bis(1,4-dimethylpentyl)-p-phenylenediamine
- Cas Number:
- 3081-14-9
- Molecular formula:
- C20H36N2
- IUPAC Name:
- N1,N4-bis(5-methylhexan-2-yl)benzene-1,4-diamine
- Details on test material:
- Santoflex 77 (purity: 96%)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 501, 631, 794, 1000 mg/kg bw
- No. of animals per sex per dose:
- 5 (combined males and females)
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 730 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 690 - 770
- Remarks on result:
- other: Signs of intoxication: reduced appetite and activity (four to six days in survivors), increasing weakness, collapse, and death; gross autopsy (decedents): hemorrhagic areas of the lungs, liver discoloration and acute gastrointestinal inflammation
Any other information on results incl. tables
Mortality
501 mg/kg: male (1/2), female (0/3), combinded (1/5)
631 mg/kg: male (1/3), female (0/2), combinded (1/5)
794 mg/kg: male (1/2), female (2/3), combinded (3/5)
1000 mg/kg: male (3/3, female (2/2), combinded (5/5)
Time of mortality: Two to seven days after test substance application, most deaths occured in four days
Clinical signs:
Reduced appetite and activity (four to six days in survivors), increasing weakness, collapse, and death
Gross autopsy
Decedents: hemorrhagic areas of the lungs, liver discoloration and acute gastrointestinal inflammation
Survivors (10 day): viscera appeared normal
Applicant's summary and conclusion
- Executive summary:
LD50 rat: 730 mg/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
