Registration Dossier
Registration Dossier
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EC number: 700-352-1 | CAS number: 62756-44-9
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: recent test according calidated method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- (pyridin-3-yl)methanol hydrofluoride
- EC Number:
- 700-352-1
- Cas Number:
- 62756-44-9
- Molecular formula:
- C6H8FNO
- IUPAC Name:
- (pyridin-3-yl)methanol hydrofluoride
Constituent 1
Method
- Target gene:
- Salmonella thiphymurium TA98 --> his D
Salmonella thiphymurium TA1537 --> his C
Salmonella thiphymurium TA100 --> his G
Salmonella thiphymurium TA1535 --> his G
Escherichia coli WP2 (pKM101) --> uvrA
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 mix
- Test concentrations with justification for top dose:
- 50, 150, 500, 1500 and 5000 µg/plate
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Species / strain:
- E. coli WP2 uvr A pKM 101
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
There is no evidence of any increase in the number of revertant colonies in the presence of the test substance (5000, 1500, 500, 150 and 50 µg/plate)without and with metabolic activation for bacterial strains in Salmonella typhymurium TA1535, TA1537, TA98, TA100 and Escherichia coli WP2(uvrA) (pKM101).
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