1,3-Oxathiolane-2-carboxylic acid, 5-hydroxy-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, (2R,5R)-

Guidance on Safe Use

First-aid measures

Description of first aid measures:

Pay attention to self-protection.

Remove victims from hazardous area.

Immediately remove soiled or soaked clothing and remove it to a safe distance.

Keep victim warm, in a stabilized position and covered.

Do not leave victims unattended.

If the casualty is unconscious: Place the victim in the recovery position.

Inhalation:

Potential for exposure by inhalation if dusts or smoke are generated.

Move victims into fresh air.

With labored breathing: Provide with oxygen. Consult a doctor immediately.

If the casualty is not breathing: Perform mouth-to-mouth resuscitation, notify emergency physician immediately.

Skin contact:

Wash off affected area immediately with plenty of water.

Continue decontamination with polyethylene glycol 400 after initial rinsing with water and then wash with water and soap.

If symptoms persist, consult a physician for treatment.

Eye contact:

With eye held open, thoroughly rinse immediately with plenty of water for at least 10 minutes.

Consult an ophthalmologist immediately if the symptoms persist.

Ingestion:

Rinse out mouth.

Immediately give large quantities of water to drink.

Consult a physician immediately.

Most important symptoms and effects, both acute and delayed:

Indication of any immediate medical attention and special treatment needed:

The initial focus is only on the local action, possibly characterized by a progressive tissue irritation.

In the eye, irritating solids cause, depending on the intensity of exposure, irritation of the conjunctiva and, in exceptional cases, damage to the cornea.

There is a danger of blindness if corneas are damaged!

Superficial irritations and only infrequent damage with ulcerations develop on the skin.

Fire-fighting measures

Extinguishing media:

Suitable extinguishing media: Water, water vapour, extinguishing powder, extinguishing foam.

Unsuitable extinguishing media:

Do not use a solid water stream as it may scatter and spread fire.

Special hazards arising from the substance or mixture:

In the case of fire, the following hazardous smoke fumes may be produced:

Carbon monoxide, carbon dioxide, sulphur oxides.

Under certain fire conditions, traces of other toxic products may occur.

Advice for firefighters:

Contaminated extinguishing water must be treated at a suitable disposal plant in accordance with waste management laws.

Water used to extinguish fire should not enter drainage systems, soil or stretches of water.

In case of fire, remove the endangered containers and bring to a safe place, if this can be done safely.

Use water spray to cool unopened containers.

Fire residues should be disposed of in accordance with the regulations.

Pay attention to self-protection.

Keep out unprotected persons.

In case of fire: full protective suit and wear a self contained respiratory apparatus.

Accidental release measures

Personal precautions, protective equipment and emergency procedures:

Keep unauthorized persons away.

Avoid dust formation.

Environmental precautions:

Observe regulations on prevention of water pollution (check, dam up, cover up).

Do not allow entrance in sewage water, soil, stretches of water, drainage systems, surface water.

If the product contaminates rivers and lakes or drains inform respective authorities.

Methods and material for containment and cleaning up:

Pick up mechanically and collect in a suitable container.

Avoid formation of dust.

To absorb spilled substance an approved industrial vacuum cleaner is recommended.

If necessary, the spilled substance should be moistened.

Clean contaminated surface thoroughly.

Pack and label wastes like the pure substance.

Do not detach label from the delivery containers prior to disposal.

Disposal according to local authority regulations.

Reference to other sections:

Wear personal protective equipment.

Handling and storage

Precautions for safe handling:

Use permissible in closed systems only.

Handle and transfer product in closed systems only (gas displacement device).

Ensure that apparatus and pipelines are free from leaks.

Do not ventilate into the open.

Dedicated loading/unloading stations required.

Take precautionary measures against static discharges.

Empty, clean and dry system / system components completely before maintenance and repair work is done.

Written approval necessary in case of non-routine jobs, e.g. maintenance activities.

Conditions for safe storage, including any incompatibilities:

Advice on protection against fire and explosion:

Normal measures for preventive fire protection.

Ensure there are sufficient retaining facilities for water used to extinguish fire.

VDI 2263 "Dust fires and dust explosions; dangers, evaluation, preventive measures."

Storage:

Store in the original receptacle, keeping this tightly sealed, under cool and dry conditions.

Further information:

In the event of internal transportation, already-opened containers are to be kept closed in order to avoid spillage.

In order to ensure due transportation, make certain that stacks are of the correct height, containers are securely fastened so as not to fall off, and labelled according to the regulations.

Protect from sunlight, warmth and heat.

Advice on common storage:

Observe prohibition against storing together!

German storage class:

Combustible / non-combustible liquids and solids not assigned to other storage classes.

Dust explosion class:

Considerable danger of dust explosion.

Must be rendered inert for grinding.

Transport information

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Shipping

Remarks

Additional transport information

Additional information

Special provisions / remarks / other:

Not relevant (on-site isolated intermediate).

Exposure controls / personal protection

Control parameters:

DNEL/DMEL values

Remarks : No substance-related safety assessment is necessary / has been conducted for this product.

PNEC values:

Remarks: No substance-related safety assessment is necessary / has been conducted for this product.

Exposure controls:

Engineering measures:

Refill and handle product only in closed system.

Minimization of emissions by means of suitable technical measures such as flanges and valves with low leakage rates, recirculation of vapours.

All precautionary measures indicated have to be observed.

Do not add wastewater to a biological wastewater treatment plant.

Ensure suitable suction/aeration at the work place and with operational machinery.

Avoid formation of dust.

Earthing of equipment.

Provide for installation of emergency shower and eye bath.

Exposure controls:

The substance must be handled under strictly controlled conditions in accordance with Article 17 of the REACH regulation.

Personal protective equipment:

Respiratory protection:

When handling for a short time:

Respirator with ABEK-P2 combination filter.

Accidental release measures:

Wear a self contained respiratory apparatus.

Note time limit for wearing respiratory protective equipment.

Hand protection:

Glove material:        Nitrile, for example, Dermatril 740, Kächele-Cama Latex GmbH (KCL), Germany

Material thickness: 0.11 mm

Method: DIN EN 374

Accidental release measures:

Glove material: Nitrile/Chloroprene, for example, Nitopren 717, Kächele-Cama Latex GmbH (KCL), Germany

Material thickness: 0.65 mm

Method: DIN EN 374.

Eye protection:

Safety glasses with side-shields conforming to EN166

or

Accidental release measures:

Close-fitting protective goggles (e.g. closed goggles).

Skin and body protection:

Select materials and equipment for physical protection depending on the concentration and volume of hazardous substances and the workplace involved.

Hygiene measures:

Do not eat, drink, smoke, or sniff while at work.

Wash your hands and/or face before breaks and before termination of work.

Take off contaminated clothing and wash before reuse.

Preventive skin protection is recommended.

Use barrier cream regularly.

Protective measures:

All precautionary measures indicated have to be observed.

Risk assessment and risk monitoring of all work places required.

Health, Safety and Emergency Management System recommended.

Regular safety training is a must.

The personal protective equipment used must meet the requirements of directive 89/686/EEC and amendments (CE certification).

It should be defined in the work place in the form of a risk analysis according to directive 89/686/EEC and amendments.

Stability and reactivity

Reactivity:

No further information available.

Chemical stability:

No further information available.

Possibility of hazardous reactions:

No further information available.

Conditions to avoid:

No dangerous reaction known under conditions of normal use.

Incompatible materials:

No further information available.

Hazardous decomposition products:

No further information available.

Disposal considerations

Waste treatment methods:

Product:

Strictly controlled conditions during disposal or treatment to air, wastewater and waste.

Do not add wastewater to a biological wastewater treatment plant.

Bring used exhaust air filter for incineration.

Disposal according to local authority regulations.

Uncleaned packaging:

Do not reuse empty containers and dispose of in accordance with the regulations issued by the appropriate local authorities.

Waste Key Number:

The waste key number must be determined as per the European Waste Types List (decision on EU Waste Types List 2000/532/EC) in cooperation with the disposal firm / producing firm / official authority.