Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 256-032-2 | CAS number: 42978-66-5
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The inhibition of the degradation activity of activated sludge is not anticipated when TPGDA introduced in appropriate low concentrations.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 000 mg/L
- EC10 or NOEC for microorganisms:
- 1 000 mg/L
Additional information
For assessment of ecotoxicity of Tripropylenglykoldiacrylate (TPGDA, CAS 42978-66-5) to aquatic microorganisms a weight-of-evidence approach was used. This approach consists of three available experimental studies.
In a short-term respiration test a 30 -min EC10 of > 10000 mg/L were determined, using the Pseudomonas putida species as inoculum. Hence, the30 -min EC50 is also >10000 mg/L (BASF AG, 1988, rep no.: 01/88/0671).
In a GLP guideline study conducted according to OECD 209 the structurally similar substance CAS 57472-68-1 was tested with domestic activated sludge. In this study a 30-min EC20 was determined to be > 1000 mg/L (BASF AG, rep no.: 02/0368/08/1, 2002).
In addition, Tripropylenglykoldiacrylate (TPGDA, CAS 42978-66-5) was tested in a Warbung-Test, DEV/L2. Activated sludge was used as a test organism in this study. The 30-min EC20 was determined to be > 1000 mg/L. However, this study is poor documented and, therefore, not reliable for the assessment.
Overall it can be considered, that the lowest ECx value is higher than 1000 mg/L. Thereofore, this value was used as a worst-case for the derivation of the PNECs STP.
Therefore, based on the weight-of-evidence approach, it can be concluded, that the inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
