Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
202-966-0
CAS no.:
101-68-8
Index number:
Molecular formula:
C15H10N2O2
SMILES:
O=C=NC1=CC=C(CC2=CC=C(C=C2)N=C=O)C=C1
InChI:
InChI=1S/C15H10N2O2/c18-10-16-14-5-1-12(2-6-14)9-13-3-7-15(8-4-13)17-11-19/h1-8H,9H2
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
26
Of which contain:
2 impurities relevant for classification
1 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance causes serious eye irritation, is harmful if inhaled, is suspected of causing cancer, may cause damage to organs through prolonged or repeated exposure, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may cause respiratory irritation.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is toxic if inhaled and may cause damage to organs.

Breakdown of all 1506 C&L notifications submitted to ECHA

Resp. Sens. 1 H334 Harmonised Classification
Eye Irrit. 2 H319 Harmonised Classification
Carc. 2 H351 Harmonised Classification
Skin Irrit. 2 H315 Harmonised Classification
Acute Tox. 4 H332 Harmonised Classification
STOT RE 2 H373 Harmonised Classification
STOT SE 3 H335 Harmonised Classification
Skin Sens. 1 H317 Harmonised Classification
Skin Sens. 1B H317
Acute Tox. 3 H331
STOT SE 2 H371
STOT SE 3 H370
Skin Irrit. 2 H314
Acute Tox. 2 H330
Muta. 2 H341
https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • C
Suspected to be Carcinogenic (Harmonised C&L).
  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (100% of REACH registrations).
  • Sr
Officially recognised in the EU as Respiratory sensitising ( Harmonised C&L).
  • Sr
There is broad agreement in that a majority of data submitters agree this substance is Respiratory sensitising (100% of REACH registrations).

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 54 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):
Some uses of this substance are restricted under Annex XVII of REACH.

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 100 000 - 1 000 000 tonnes per year.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: adhesives and sealants, coating products and polymers.

Other release to the environment of this substance is likely to occur from: indoor use and outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: adhesives and sealants and coating products.

This substance is used in the following areas: building & construction work, health services and printing and recorded media reproduction. This substance is used for the manufacture of: machinery and vehicles.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, roller or brushing applications, batch processing in synthesis or formulation with opportunity for exposure, non-industrial spraying, closed batch processing in synthesis or formulation, treatment of articles by dipping and pouring and the low energy manipulation of substances bound in materials or articles.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following products: coating products, inks and toners, polymers and cosmetics and personal care products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, laboratory work, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, formulation in materials, for thermoplastic manufacture and in the production of articles.

This substance is used in the following products: adhesives and sealants and coating products.

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, laboratory work, closed batch processing in synthesis or formulation, mixing in open batch processes, batch processing in synthesis or formulation with opportunity for exposure, closed, continuous processes with occasional controlled exposure, roller or brushing applications, industrial spraying and the low energy manipulation of substances bound in materials or articles.

Release to the environment of this substance can occur from industrial use: for thermoplastic manufacture, in the production of articles, in processing aids at industrial sites, formulation of mixtures, formulation in materials and as an intermediate step in further manufacturing of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, laboratory work, batch processing in synthesis or formulation with opportunity for exposure and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, formulation of mixtures and for thermoplastic manufacture.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not breathe the dust, fume, gas, mist, vapours or spray; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; wear respiratory protection.

Response statements

In case of incident: If exposed or concerned: get medical advice/attention. If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. If on skin: wash with soap and water.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL, Hermeslaan 7 1831 Diegem Belgium
  • AKZO Nobel Car Refinishes B.V., Rijksstraatweg 31 2170 BA Sassenheim Netherlands
  • Axalta Coating Systems Germany GmbH & Co. KG, Christbusch 25 42285 Wuppertal Germany
  • BASF Antwerpen N.V., Haven 725, Scheldelaan 600 2040 Antwerpen 4 Antwerpen Belgium
  • BASF Italia S.p.A., Via Marconato 8 20811 Cesano Maderno Italy
  • BASF Polyurethanes GmbH, Elastogranstr. 60 49448 Lemförde Niedersachsen Germany
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • BorsodChem, Bolyai ter 1 3700 Kazincbarcika Hungary
  • BorsodChem Zrt. - OR, Bolyai ter 1. H-3700 Kazincbarcika Hungary
  • Caplinq Europe B.V., De Trompet 1126 1967 DA Heemskerk Netherlands
  • Celanese Europe BV, The New Atrium Strawinskylaan 3105 1077 ZX Amsterdam Netherlands
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED(EPOXY BASE ELECTRONIC MATERIAL CORPORATION LIMITED), Room 002, Regus Harcourt Centre D02 HW77, Dublin, Ireland D02 Dublin Ireland
  • Chemours Netherlands B.V., Baanhoekweg 22 3313 LA Dordrecht Netherlands
  • Chemservice S.A. (TZ6C), 5, an de Laengten 6776 Grevenmacher Luxembourg
  • COIM SpA, Via Manzoni 28/32 20019 Settimo Milanese (MI) Italy
  • Covestro Deutschland AG, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Covestro Deutschland AG OR CN_001554, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Covestro Deutschland AG OR JP_000145, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Covestro Deutschland AG OR US_001257, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • COVESTRO, S.L., C/. Feixa LLarga, 7 08040 Barcelona Spain
  • CSI-OR008, Pentlands Science Park Penicuik EH26 0PZ Edinburgh United Kingdom
  • DOW BENELUX B.V., Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. - OR1, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR-10, Postbus 48 4530 AA Terneuzen Netherlands
  • FujiFilm Manufacturing Europe BV, Oudenstaart 1 5047 TK Tilburg Netherlands
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • Huntsman (Europe) BVBA - OR2, Everslaan 45 B-3078 Everberg Belgium
  • Huntsman (Europe) BVBA - OR8, Everslaan 45 B-3078 Everberg Belgium
  • HUNTSMAN HOLLAND BV, Merseyweg 10 3197 KG Botlek-Rotterdam Netherlands
  • Jowat SE, Ernst-Hilker-Str. 10 - 14 32758 Detmold NRW Germany
  • Kuraray Europe GmbH (OR1), Philipp-Reis-Str. 4 65795 Hattersheim Germany
  • Lubrizol Advanced Materials Europe B.V.B.A, Nijverheidsstraat 30 2260 Westerlo-Oevel Belgium
  • Lubrizol Europe Coordination Center BVBA 02 , Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 19, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 30, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol France SAS, 25 Quai de France 76100 ROUEN France
  • Lubrizol Limited, The Knowle, Nether Lane Hazelwwod DE56 4AN Derby Derbyshire United Kingdom
  • Mitsui and Co. Deutschland G.M.B.H. Head Office (Düsseldorf), Herzogstrasse 15 D-40217 Düsseldorf Germany
  • Nesperta sp. z o.o. , Rejtana 12 A 62-030 Luboń Poland
  • PPG Europe B.V. - OR1, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. - OR3, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. in its legal capacity as Only Representative of PRC DeSoto International Inc. - OR5, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • Ramboll Environment & Health GmbH, Werinherstr. 79 Gebäude 32a 81541 München Bayern Germany
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • Renishaw PLC, New Mills GL12 8JR Wotton-under-Edge Gloucestershire United Kingdom
  • SAINT-GOBAIN INNOVATIVE MATERIALS BELGIUM SA, AVENUE EINSTEIN 6 1300 WAVRE Belgium
  • SLM Solutions Group AG, Estlandring 4 23560 Lübeck Germany
  • Specialty Electronic Materials Netherlands B.V. OR-1, Herbert H. Dowweg 5 4542NM Hoek Netherlands
  • StonCor Europe, Rue du Travail, 9 1400 Nivelles Belgium
  • TSE, OR for NPU, Amstelplein 1 1096 HA Amsterdam Netherlands
  • W. L. Gore & Associates (UK) Ltd., Kirkton South Road Kirkton Campus EH54 7BT Livingston United Kingdom
  • W. L. Gore & Associates GmbH, Hermann-Oberth-Strasse 22 85640 Putzbrunn Germany
  • Yordas GmbH, Äußere Nürnberger Str. 62, 91301 Forchheim Germany
  • [Confidential], [Confidential]
  • Arcerion GmbH, Gabrielenstr. 15 80636 Muenchen Germany
  • Lohmann & Rauscher GmbH & Co. KG, Irlicher Straße 55 56567 Neuwied Germany

Substance names and other identifiers

4,4'-methylenediphenyl diisocyanate
EC Inventory, C&L Inventory, REACH pre-registration
4,4’-Methylenediphenyl diisocyanate
Restriction list, Substance Evaluation - CoRAP
diphenylmethane-4,4'-diisocyanate
C&L Inventory
4,4'-diisocianato de difenilmetano (pt)
C&L Inventory
4,4'-diisocyanate de diphénylméthane (fr)
C&L Inventory
4,4'-diizocianat de difenil-metan (mt)
C&L Inventory
4,4'-methyleendifenyldiisocyanaat (nl)
C&L Inventory
4,4'-methylendifenyl diisokyanát (cs)
C&L Inventory
4,4'-methylendiphenyldiisocyanat (da)
C&L Inventory
4,4'-metilendifenil diizocianat (hr)
C&L Inventory
4,4'-metiléndifenil-diizocianát (hu)
C&L Inventory
4,4'-metilēndifenildiizocianāts (lv)
C&L Inventory
4,4'-Metyleenidifenyylidi-isosyanaatti (fi)
C&L Inventory
4,4'-metylendifenyldiisocyanat (no)
C&L Inventory
4,4'-metylenobis(fenyloizocyjanian) (pl)
C&L Inventory
4,4'-metyléndi(fenylizokyanát) (sk)
C&L Inventory
4,4'-metüleendifenüüldiisotsüanaat (et)
C&L Inventory
4,4'-метилендифенил диизоцианат (bg)
C&L Inventory
4,4′-metilendifenildiizocianatas (lt)
C&L Inventory
bis(4-diizocyjanianofenylo)metan (pl)
C&L Inventory
difenilmetan-4,4'-diisocianato (it)
C&L Inventory
difenilmetan-4,4'-diizocianat (hr)
C&L Inventory
difenilmetan-4,4′-diizocianatas (lt)
C&L Inventory
difenilmetán-4,4'-diizocianát (hu)
C&L Inventory
difenilmetāna-4,4'-diizocianāts (lv)
C&L Inventory
difenylmetan-4,4'-diisocyanat (no)
C&L Inventory
difenylmethaan-4,4'-diisocyanaat (nl)
C&L Inventory
difenylmethan-4,4'-diisokyanát (cs)
C&L Inventory
difenylmetán-4,4'-diizokyanát (sk)
C&L Inventory
difenyylimetaani-4,4'-di-isosyanaatti (fi)
C&L Inventory
difenüülmetaan-4,4'-diisotsüanaat (et)
C&L Inventory
diisocianato de 4,4'-difenilmetano (es)
C&L Inventory
diisocianato de 4,4'-metilendifenilo (es)
C&L Inventory
diisocianato de 4,4'metilenodifenilo (pt)
C&L Inventory
diisocianato di 4,4'-metilendifenile (it)
C&L Inventory
diisocyanate de 4,4'-méthylènediphényle (fr)
C&L Inventory
diizocianat de 4,4'-metilen-difenil (mt)
C&L Inventory
diizocyjanian 4,4'-metylenodifenylu) (pl)
C&L Inventory
diphenylmethan-4,4'-diisocyanat (da)
C&L Inventory
διισοκυανικό 4,4'-διφαινυλομεθάνιο (el)
C&L Inventory
διισοκυανικό 4,4'-μεθυλενοδιφαινύλιο (el)
C&L Inventory
дифенилметан-4,4'-диизоцианат (bg)
C&L Inventory
Benzene, 1,1'-methylenebis[4-isocyanato-
Other
1,1'-methanediylbis(4-isocyanatobenzene)
C&L Inventory
1,1'-methylenebis(4-isocyanatobenzene)
C&L Inventory, Registration dossier
1-isocyanato-4-(4-isocyanatobenzyl)-benzeen
C&L Inventory
1-isocyanato-4-[(4-isocyanatophenyl)methyl] benzene
C&L Inventory
1-isocyanato-4-[(4-isocyanatophenyl)methyl]benzene
C&L Inventory, Registration dossier, Other
4,4 - methylenediphenyl diisocyanate
C&L Inventory
4,4 methylenediphenyldiisocyanate
C&L Inventory
4,4'-DIISOCIANATO DE DIFENIL-METILENO
C&L Inventory
4,4'-Diisocyanatodiphenylmethane
C&L Inventory
4,4'-DIPHENYLMETHANE DIISOCYANATE
C&L Inventory, Registration dossier
4,4'-MDI
Registration dossier
4,4'-Methylendiphenyl diisocyanate
C&L Inventory
4,4'-methylenediphenyl diisocyanate1,1'-methanediylbis(4-isocyanatobenzene)1,1'-methylenebis(4-isocyanatobenzene)1-isocyanato-4-[(4-isocyanatophenyl)methyl] benzene1-isocyanato-4-[(4-isocyanatophenyl)methyl]benzene4,4 - methylenediphenyl diisocyanate4,4 methylenediphenyldiisocyanate4,4'-DIISOCIANATO DE DIFENIL-METILENO4,4'-Diisocyanatodiphenylmethane4,4'-DIPHENYLMETHANE DIISOCYANATE4,4'-Methylendiphenyl diisocyanate4,4'-Methylenediphenyl diisocyanateBenzene, 1,1'-methylenebis[4-isocyanato-difenylmethan-4,4'-diisokyanátDiisocyanate of 4,4 '-methylenediphenylDiphenylmethane diisocyanateDIPHENYLMETHANE-4,4'-DI-ISOCYANATEdiphenylmethane-4,4'-diisocyanateMDI, MMDI, Pure >MDI, rein MDI, 4,4'-MDI,MDI, MMDI, Pure MDI, Rein MDI, 4,4`-MDIMethylene diphenyl diisocyanateMethylenediphenyl 4,4'-Diisocyanate
Registration dossier
Diisocyanate of 4,4 '-methylenediphenyl
C&L Inventory
Diphenylmethane diisocyanate
C&L Inventory
DIPHENYLMETHANE-4,4'-DI-ISOCYANATE
C&L Inventory
MDI
Registration dossier
MDI, MMDI, Pure >MDI, rein MDI, 4,4'-MDI,
Registration dossier
MDI, MMDI, Pure MDI, Rein MDI, 4,4`-MDI
Registration dossier
Methylene diphenyl diisocyanate
C&L Inventory
Methylenediphenyl 4,4'-Diisocyanate
C&L Inventory
1,1`-methylenebis(4-isocyanatobenzene)
Registration dossier
4,4'-Methylenebis(isocyanatobenzene)
Registration dossier
4,4'-Methylenebis(phenyl isocyanate)
Registration dossier
4,4'-Methylenebis(phenylisocyanate)
Registration dossier
4,4'-Methylenediphenyldiisocyanate
Registration dossier
4,4'Methylendi-p-phenylenediisocyanate
Registration dossier
4,4`-Diisocyanatodiphenylmethane
Registration dossier
4,4`-MDI
Registration dossier
4,4`-Methylenebis(phenyl isocyanate)
Registration dossier
4,4`-Methylenedi-p-phenylenediisocyanate
Registration dossier
4,4`-Methylenediphenyldiisocyanate
Registration dossier
4,4`-Methylenediphenylene isocyanate
Registration dossier
4,4´-Diphenylmethane diisocyanate
Registration dossier
4,4´-Methylenebis(isocyanatobenzene)
Registration dossier
Benzene, 1,1'-methylenebis(4-isocyanato-(9CI))
Registration dossier
Benzene, 1,1`-methylenebis(4-isocyanato-(9CI)
Registration dossier
Bis(1,4-isocyanatophenyl)methane
Registration dossier
Bis(4-isocyanatophenyl)methane
Registration dossier
Bis(p-isocyanatophenyl)methane
Registration dossier
Desmodur 44 M
Registration dossier
Di(4-isocyanatophenyl)methane
Registration dossier
Diphenylmethane 4,4`-diisocyanate
Registration dossier
Diphenylmethanediisocyanate
Registration dossier
Diphenylmethylene diisocyanate
Registration dossier
Diphenymethane-4,4'-diisocyanate
Registration dossier
isocyanaic acid, methylene di-p-phenyleneester(6CI,8CI)
Registration dossier
Isocyanic acid, diphenylmethylene ester
Registration dossier
Isocyanic acid, methylenedi-p-phenylene ester (6CI, 8CI)
Registration dossier
Isocyanic acid, methylenedi-p-phenylene ester (6CI,8CI)
Registration dossier
ISONATE* M124
Registration dossier
ISONATE* M125
Registration dossier
ISONATE* M125 M
Registration dossier
methylene-di-p-phenylene diisocyanate
Registration dossier
Methylenebis(4-isocyanatobenzene)
Registration dossier
Methylenebis(4-phenyl isocyanate)
Registration dossier
Methylenebis(4-phenylene isocyanate)
Registration dossier
Methylenebis(p-phenyl isocyanate)
Registration dossier
Methylenebis(p-phenylene isocyanate)
Registration dossier
Methylenebis-p-phenylene diisocyanate
Registration dossier
Methylenebisphenylene diisocyanate
Registration dossier
Methylenebisphenylenediisocyanate
Registration dossier
Methylenedi-p-phenylene diisocyanate
Registration dossier
Methylenedi-p-phenylene isocyanate
Registration dossier
Millionate
Registration dossier
Name
Registration dossier
p,p'-Diphenylmethane diisocyanate
Registration dossier
p,p'-Methylenebis(phenyl isocyanate)
Registration dossier
p,p`-Diphenylmethane diisocyanate
Registration dossier
p,p`-Methylenebis(phenyl isocyanate)
Registration dossier
101-68-8
CAS number
EC Inventory, C&L Inventory, Restriction list, Substance Evaluation - CoRAP, Registration dossier, REACH pre-registration, Other
1211266-59-9
Deleted CAS number
Other
1211316-64-1
Deleted CAS number
Other
1220313-65-4
Deleted CAS number
Other
1400594-70-8
Deleted CAS number
Other
142690-07-1
Deleted CAS number
Other
1533423-48-1
Deleted CAS number
Other
153986-89-1
Deleted CAS number
Other
1588489-56-8
Deleted CAS number
Other
201528-77-0
Deleted CAS number
Other
2031250-39-0
Deleted CAS number
Other
2056146-02-0
Deleted CAS number
Other
53633-14-0
Deleted CAS number
Other
55157-41-0
Deleted CAS number
Other
57460-66-9
Deleted CAS number
Other
615-005-00-9
Index number
C&L Inventory
77090-48-3
Deleted CAS number
Other
88001-94-9
Deleted CAS number
Other
97568-33-7
Deleted CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Crystalline (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 1 study submitted
  • 1 study processed
R Melting / freezing point
39 - 43 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
42 °C

Boiling point

Study results
  • 1 study submitted
  • 1 study processed
R Boiling point
300 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 1 study submitted
  • 1 study processed
R Density
1.18 g/cm³ @ 50 °C [1]
R Relative density
1.32 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
1.32

Vapour pressure

Study results
  • 4 studies submitted
  • 1 study processed
R Vapour pressure
0.001 Pa @ 20 °C [1]

Type of Study provided
Studies with data
Key study
Supporting study 3
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
0.001 Pa @ 20 °C

Partition coefficient

Study results
  • 1 study submitted
  • 1 study processed
R Log Pow
4.51 @ 22 °C and pH 7 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
4.51 @ 20 °C

Water solubility

Study results
  • 2 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
6.8 mg/L @ 25 °C and pH 7 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
6.8 mg/L @ 25 °C

Solubility in organic solvents / fat solubility

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 2 studies submitted
  • 1 study processed
R Flash point
211 °C @ 100 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 1 study submitted
  • 1 study processed
R Autoflammability / self-ignition
601 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 3 studies submitted
  • 2 studies processed
C Interpretation of results
Non flammable (100%) [2]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

pH

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 3 studies submitted
  • 1 study processed
R Dissipation half life (DT50)
22.08 h [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
24 h

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life for hydrolysis
20 h @ 25 °C

Phototransformation in water

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in soil
24 h @ 22 °C

Bioaccumulation: aquatic / sediment

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - dimensionless
200

Bioaccumulation: terrestrial

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 1 mg/L (1)
Intermittent releases (freshwater) 10 mg/L (1)
Marine water 100 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 1 mg/L (1)
Sediment (freshwater) No data available: testing technically not feasible (1)
Sediment (marine water) No data available: testing technically not feasible (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 1 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 days) 1 g/L [1]
LC0 (4 days) 3 g/L [1]
LC0 (72 h) 3 g/L [1]
LC0 (48 h) 3 g/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
LC50 for freshwater fish
1 g/L

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
EC50 (24 h) 129.7 - 1 000 mg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
1 g/L

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (21 days) 10 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater invertebrates
10 mg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (72 h) 1.64 g/L [1]
NOELR (72 h) 1.64 g/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
1.64 g/L
EC10 or NOEC for freshwater algae
1.64 g/L

Toxicity to aquatic plants other than algae

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (3.733 months) 10 g/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to microorganisms

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (3 h) 100 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
100 mg/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (14 days) 1 g/kg soil dw [1]
LC50 (14 days) 1 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
1 g/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
NOEC (14 days) 1 g/kg soil dw [6]
EC50 (14 days) 1 g/kg soil dw [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
1 g/kg soil dw

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: (DNEL) 50 µg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 100 µg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: (DNEL) 25 µg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 50 µg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
Medium hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 20 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 3
Supporting study 7 4
Weight of evidence
Other 6
Data waiving
no waivers
Study data: dermal absorption
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 6 studies submitted
  • 1 study processed
P/RResults
LD50 2 000 mg/kg bw (rat) [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 3
Data waiving
no waivers
inhalation
  • 14 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 h) 367.95 - 558.98 mg/m³ air (rat) [5]
M/CInterpretations of results
Highly toxic [1]

inhalation
Studies with data
Key study 1 1
Supporting study 6 2
Weight of evidence
Other 3 1
Data waiving
no waivers
dermal
  • 2 studies submitted
  • 1 study processed
P/RResults
LD50 9 400 mg/kg bw (rabbit) [1]
M/CInterpretations of results
Practically nontoxic [1]

dermal
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other 1 1
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Inhalation route:
Adverse effect observed LC50 431 mg/m³

Irritation / corrosion

Study results
Study data: skin
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: eye
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 2 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: respiratory
  • 16 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study 1 1
Supporting study 8 6
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
Adverse effect observed (sensitising)
Respiratory sensitisation
Adverse effect observed (sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 3 studies submitted
  • 1 study processed
P/RResults
NOAEC (rat): 190 - 200 µg/m³ air [2]
LOAEC (rat): 980 - 1 000 µg/m³ air [2]

Study data: inhalation
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Inhalation route - systemic effects:
Adverse effect observed LOAEC 1 mg/m³ (chronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 1
Supporting study 4 1
Weight of evidence
Other 1 1
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons.
Other
Study data: in vivo
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 3
Supporting study 3 1
Weight of evidence
Other 3
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1 3
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Inhalation route:
Adverse effect observed NOAEC 1 mg/m³ (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study 1 2
Weight of evidence 2
Other
Data waiving
no waivers
Study data: developmental
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Inhalation route:
No adverse effect observed NOAEC 200 µg/m³ (chronic, rat)
Effect on developmental toxicity
Inhalation route:
No adverse effect observed NOAEC 4 mg/m³ (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant