Brief Profile

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Please be aware that the REACH registration parts of this Brief Profile are no longer maintained; they remain frozen as of 19th May 2023. All other data parts (substance identity, C&L, key regulatory lists etc. are up to date).

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
201-236-9
CAS no.:
79-94-7
Index number:
604-074-00-0
Molecular formula:
C15H12Br4O2
SMILES:
CC(C)(C1=CC(Br)=C(O)C(Br)=C1)C1=CC(Br)=C(O)C(Br)=C1
InChI:
InChI=1S/C15H12Br4O2/c1-15(2,7-3-9(16)13(20)10(17)4-7)8-5-11(18)14(21)12(19)6-8/h3-6,20-21H,1-2H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
8
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance is very toxic to aquatic life and is very toxic to aquatic life with long lasting effects.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is suspected of causing cancer.

Breakdown of all 717 C&L notifications submitted to ECHA

Aquatic Acute 1 H400 Harmonised Classification
Aquatic Chronic 1 H410 Harmonised Classification
Carc. 2 H351
Aquatic Chronic 2 H410
Eye Irrit. 2A H319
Skin Irrit. 2 H315
STOT SE 3 H335
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • C
Officially recognised in the EU as Carcinogenic (Candidate list of SVHCs).
  • PBT
Under assessment as Persistent, Bioaccumulative and Toxic (PBT list).
  • PBT
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Persistent, Bioaccumulative and Toxic (5.88% of REACH registrations).
  • ED
Under assessment as Endocrine Disrupting (ED list).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 12 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Substance of very high concern (SVHC) and included in the candidate list for authorisation.
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Industrial accident prevention and reporting requirements have been established for this substance.
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing and at industrial sites.

This substance is used in the following products: polymers.

Other release to the environment of this substance is likely to occur from: outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles, production of mixtures or articles by tabletting, compression, extrusion or pelletisation and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal) and in the production of articles. Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance can be found in complex articles, with no release intended: machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines). This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones).

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following areas: building & construction work.

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles.

Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance is used in the following products: polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, transfer of substance into small containers and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: formulation in materials and in the production of articles.

This substance is used in the following products: polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: plastic products, chemicals, electrical, electronic and optical equipment and machinery and vehicles.

This substance is used in the following activities or processes at workplace: transfer of chemicals, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: in the production of articles, for thermoplastic manufacture, as processing aid and in processing aids at industrial sites.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: obtain special instructions before use; avoid release to the environment; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If exposed or concerned: get medical advice/attention. Collect spillage.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL (OR1), Hermeslaan 7 1831 Diegem Belgium
  • ALBEMARLE EUROPE SPRL, Parc Scientifique (Einstein) Rue du Bosquet 9 1348 LOUVAIN-LA-NEUVE Belgium
  • CS Regulatory Ireland Ltd. in its legal capacity as Only Representative of LANXESS Corporation, Alexandra House The Sweepstakes D04 C7H2 Dublin Ballsbridge Ireland
  • ICL Europe Coöperatief U.A. (OR1), Koningin Wilhelminaplein 30 Prinsenhof 1062 KR Amsterdam Netherlands
  • LANXESS Performance Materials GmbH, Kennedyplatz 1 50569 Cologne Germany
  • LANXESS Sales Netherlands B.V., Groot Egtenrayseweg 23 5928 PA Venlo Netherlands
  • LG Chem Europe GmbH, Alfred Herrhausen Allee 3 5 D-65760 Eschborn Germany
  • Red Orchid Consulting Oy Ltd, Viherkallionkuja 3 I 59 02710 Espoo Finland
  • SABIC Innovative Plastics BV, Plasticslaan 1 4612 PX Bergen op Zoom Netherlands Netherlands
  • TOSOH EUROPE B.V., Amstelplein 1 1096 HA Amsterdam Netherlands
  • Westlake Epoxy B.V., Seattleweg 17, building 4 3195 ND Pernis-Rotterdam Netherlands
  • [Confidential], [Confidential]
  • Blue Cube Netherlands B.V., Axelsedam 3a 4531HH Terneuzen Netherlands
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • SABIC Innovative Plastics Espana ScpA, Ctra. Cartagena-Alhama de Murcia km. 13. La Aljorra 30390 Cartagena Spain Spain

Substance names and other identifiers

2,2',6,6'-tetrabromo-4,4'-isopropylidenediphenol
EC Inventory
2,2',6,6'-tetrabromo-4,4'-isopropylidenediphenol
REACH pre-registration
2,2',6,6'-tetrabromo-4,4'-isopropylidenediphenol; tetrabromobisphenol-A
EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II
2,2',6,6'-Tetrabromobisphenol A
Other
2,2',6,6'-tetrabromo–4,4'-isopropylidenediphenol; tetrabromobisphenol-A
FCM Active and Intelligent Materials - CMRs not allowed for use, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, End-of-Life Vehicles Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes, Physical, Biological and Chemical Agents & Processes and Work
2,2,6,6-tetrabromo-4,4-isopropylidenediphenol
Substance Evaluation - CoRAP
Tetrabromobisphenol A
tetrabromobisphenol-A 2,2',6,6'-tetrabromo-4,4'-isopropylidenediphenol
C&L Inventory
tetrabrombifenol-A 2,2',6,6'-tetrabrom-4,4'-izopropilidendifenol (ro)
C&L Inventory
tetrabrombifenolis A 2,2',6,6'-tetrabrom-4,4'-izopropilidendifenolis (lt)
C&L Inventory
tetrabrombisfenol A 2,2',6,6'-tetrabrom-4,4'-isopropylidendifenol (no)
C&L Inventory
tetrabrombisfenol A 2,2',6,6'-tetrabromo-4,4'-isopropylidendifenol isopropylidenbis[2,6-dibromofenol] (sv)
C&L Inventory
tetrabrombisfenol A 2,2’,6,6’-tetrabrom-4,4’- propan-2,2-diyldifenol; 4,4’-propan-2,2-diylbis(2,6- dibromfenol) (cs)
C&L Inventory
tetrabrombisfenol-A 2,2',6,6'-tetrabrom-4,4'-izopropilidēndifenols (lv)
C&L Inventory
tetrabrombisphenol-A 2,2',6,6'-tetrabrom-4,4'-isopropylidendiphenol (da)
C&L Inventory
Tetrabrombisphenol-A 2,2',6,6'-Tetrabrom-4,4'-isopropylidendiphenol (de)
C&L Inventory
tetrabromibisfenoli-A 2,2’,6,6’-tetrabromi-4,4'-isopropylideenidifenoli (fi)
C&L Inventory
tetrabromobisfenol-A 2,2',6,6'-tetrabromo-4,4'-isopropilidendifenol (es)
C&L Inventory
tetrabromobisfenol-A 2,2',6,6'-tetrabromo-4,4'-isopropilidenodifenol (pt)
C&L Inventory
tetrabromobisfenol-A 2,2',6,6'-tetrabromo-4,4'-izopropilidendifenol (sl)
C&L Inventory
tetrabromobisfenol-A 2,2',6,6'-tetrabromo-4,4'-izopropylidenodifenol (pl)
C&L Inventory
tetrabromobisfenol-A 2,2',6,6'-tetrabromo-4,4'-iżopropilidendifenol (mt)
C&L Inventory
tetrabromobisfenol-A 2,2’,6,6’-tetrabromo-4,4’-isopropilidendifenolo (it)
C&L Inventory
tetrabromobisfenol-A 2,2′,6,6′-tetrabromo-4,4′-izopropilidendifenol (hr)
C&L Inventory
tetrabromobisfenool-A 2,2',6,6'-tetrabromo-4,4'-isopropülideendifenool (et)
C&L Inventory
tetrabroombisfenol-A 2,2',6,6'-tetrabroom-4,4'-isopropylideendifenol (nl)
C&L Inventory
tetrabróm-biszfenol-A 2,2',6,6'-tetrabróm-4,4'-izopropilidéndifenol (hu)
C&L Inventory
tetrabrómbisfenol-A 2,2',6,6'-tetrabróm-4,4'-(propán-2,2-diyl)difenol (sk)
C&L Inventory
tétrabromobisphénol-A; 2,2', 6,6'-tetrabromo-4,4'-isopropylidènediphénol 2,2',6,6'-tétrabromo-4,4'-isopropylidènediphénol (fr)
C&L Inventory
τετραβρωμοδιφαινόλη-A· 2,2',6,6'-τετραβρωμο-4,4'-ισοπροπυλιδενοδιφαινόλη (el)
C&L Inventory
тетрабромобисфенол-А 2,2',6,6'-тетрабромо-4,4'-изопропилидендифенол (bg)
C&L Inventory
2,2',6,6',-tetrabromo-4,4'-isopropylidenediphenol
C&L Inventory, Registration dossier
2,2',6,6'-Tetrabromo-4,4'-isopropylidenediphenol
C&L Inventory
2,2',6,6'-tetrabromo-4,4'-isopropylidenediphenol
C&L Inventory, Registration dossier
2,2’,6,6’-tetrabromo-4,4’-isopropylidenediphenol
C&L Inventory
2,6-dibromo-4-[2-(3,5-dibromo-4-hydroxyphenyl)propan-2-yl]phenol
C&L Inventory, Other
4,4'-Isopropylylidenebis(2,6-dibromophenol)
C&L Inventory
4,4'-propane-2,2-diylbis(2,6-dibromophenol)
C&L Inventory, Registration dossier
FR-1524
Registration dossier
Phenol, 4,4'-(1-methylethylidene)bis[2,6-dibromo-
C&L Inventory
Tetrabrombisphenol A
Registration dossier
TETRABROMO BISPHENOL (RM LEAD)
C&L Inventory
Tetrabromobisphenol A
C&L Inventory
Tetrabromobisphenol A, TBBA
Registration dossier
tetrabromobisphenol-A
C&L Inventory
Tetrabromobisphenol-A
Registration dossier
AP 1969
C&L Inventory
CARBONATE OLIGOMER OF TETRABROMOBISPHENOL A
Registration dossier
FR-1524
Registration dossier
Great Lakes BA-59P
Registration dossier
Great Lakes BA-59PC
Registration dossier
none, import in Epoxy Resin formulations
Registration dossier
Saytex CP-2000 Flame Retardant
Registration dossier
TBBPA
Registration dossier
Tetrabromobisphenol-A
Registration dossier
107719-55-1
CAS number
Other
108608-60-2
CAS number
Other
110670-65-0
CAS number
Other
124779-54-0
CAS number
Other
131891-38-8
CAS number
Other
186673-39-2
CAS number
Other
224951-26-2
CAS number
Other
30496-13-0
CAS number
Other
51253-31-7
CAS number
Other
604-074-00-0
Index number
C&L Inventory
7300-23-4
CAS number
Other
76341-26-9
CAS number
Other
79-94-7
CAS number
EC Inventory, C&L Inventory, Substance Evaluation - CoRAP, Registration dossier, REACH pre-registration, Other, FCM Active and Intelligent Materials - CMRs not allowed for use, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes, Physical, Biological and Chemical Agents & Processes and Work

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Powder (100%) [1]
C Odour
Odourless (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 2 studies submitted
  • 2 studies processed
R Melting / freezing point
179 - 181 °C [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
180 °C

Boiling point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 3 studies submitted
  • 2 studies processed
R Relative density
2.17 [1]
R Tap density
1.75 g/cm³ [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 3
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
2.17

Vapour pressure

Study results
  • 1 study submitted
  • 1 study processed
R Vapour pressure
0 Pa @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
0 Pa @ 20 °C

Partition coefficient

Study results
  • 3 studies submitted
  • 2 studies processed
R Log Pow
4.61 - 6.42 @ 12 - 25 °C and pH 5 - 9 [4]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
5.903 - 6.31 @ 12 - 25 °C

Water solubility

Study results
  • 5 studies submitted
  • 2 studies processed
R Water solubility (mass/vol.)
18.1 - 2 340 µg/L @ 12 - 25 °C and pH 5 - 9 [6]

Type of Study provided
Studies with data
Key study 2
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Water solubility
35.1 - 1 260 µg/L @ 12 - 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 5 studies submitted
  • 3 studies processed
C Dissociating properties
Yes (67%), Not determined (33%) [3]
R Dissociation constant
6.2 - 9.43 @ 20 °C [5]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
pKa at 20 °C
8.79 - 9.4

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 1 study submitted
  • 1 study processed
R Dissipation half life (DT50)
2.88 h [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
2.88 h

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 1 study submitted
  • 1 study processed
R Dissipation Half-life (DT50)
16 - 350 min [9]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in water
24 min

Phototransformation in soil

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 1 study submitted
  • 1 study processed
C Interpretation of results
Under test conditions no biodegradation observed (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Half-life in freshwater
19 - 29.2 days @ 12 - 25 °C
Half-life in freshwater sediment
26 days @ 25 °C

Biodegradation in soil

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Half-life in soil
6.4 - 180 days @ 12 - 20 °C

Bioaccumulation: aquatic / sediment

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - dimensionless
150

Bioaccumulation: terrestrial

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - dimensionless
5.1

Adsorption/desorption

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
416 869

Henrys law constant (H)

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Distribution modelling

Study results
  • 1 study submitted
  • 1 study processed
% Distribution in Media:
R Air 0 % [1]
R Water 0.632 % [1]
R Soil 53.2 % [1]
R Sediment 46.2 % [1]
R Aerosol 0 % [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 16 µg/L (1)
Intermittent releases (freshwater) -
Marine water 340 ng/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 1.5 mg/L (1)
Sediment (freshwater) 9 mg/kg sediment dw (1)
Sediment (marine water) 1.8 mg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 31 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning 222.22 mg/kg food (1)

Short–term toxicity to fish

Study results
  • 5 studies submitted
  • 3 studies processed
P/RResults
LC50 (6 days) 490 µg/L [1]
LC50 (4 days) 540 - 1 100 µg/L [3]
LC50 (48 h) 800 µg/L [1]
NOEC (6 days) 260 µg/L [1]
NOEC (4 days) 1.1 mg/L [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
NOEC (35 days) 160 µg/L [1]
LOEC (35 days) 310 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
LC50 (48 h) 1.8 mg/L [1]
LC50 (24 h) 1.8 mg/L [1]
NOEC (48 h) 1.8 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
NOEC (70 days) 17 µg/L [1]
NOEC (42 days) 32 µg/L [1]
NOEC (21 days) 380 µg/L [1]
NOEC (14 days) 62 µg/L [1]
LOEC (70 days) 32 µg/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
NOEC (4 days) 5.6 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for freshwater algae
5.6 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (3 h) 15 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for microorganisms
15 mg/L

Sediment toxicity

Study results
  • 5 studies submitted
  • 5 studies processed
P/RResults
NOEC (28 days) 90 - 254 mg/kg sediment dw [4]
NOEC (14 days) 39 - 46 µg/L [3]
LOEC (28 days) 151 - 500 mg/kg sediment dw [4]
EC50 (28 days) 235 - 1 000 mg/kg sediment dw [4]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater sediment
90 mg/kg sediment dw

Endocrine disrupter testing in aquatic vertebrates – in vivo

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (4.433 months) 609 µg/L [1]
LOEC (4.433 months) 609 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No summary exists for this scientific endpoint

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
NOEC (56 days) 310 µg/kg soil dw [1]
NOEC (28 days) 20 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
310 µg/kg soil dw

Toxicity to terrestrial arthropods

Data not provided by the registrant

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
NOEC (21 days) 20 - 5 000 mg/kg soil dw [6]
LOEC (21 days) 78 - 1 250 mg/kg soil dw [5]
EC50 (21 days) 459 - 5 000 mg/kg soil dw [5]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
20 mg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
EC10 (28 days) 1 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 17.6 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 250 mg/kg bw/day repeated dose toxicity
Acute /short term: No DNEL required: short term exposure controlled by conditions for long-term
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 4.3 mg/m³ developmental toxicity / teratogenicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 125 mg/kg bw/day repeated dose toxicity
Acute /short term: No DNEL required: short term exposure controlled by conditions for long-term
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.5 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Absorption values
Oral: 50 %
Dermal: 1 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 6 studies submitted
  • 1 study processed
P/RResults
LD50 5 000 mg/kg bw (rat) [1]
M/CInterpretations of results
Not classified [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 3 studies submitted
  • 1 study processed
M/CInterpretations of results
Not classified [1]

inhalation
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
dermal
  • 3 studies submitted
  • 1 study processed
M/CInterpretations of results
Not classified [1]

dermal
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 5 000 mg/kg bw
Inhalation route:
No adverse effect observed LC50 57 mg/L air
Dermal route:
No adverse effect observed LD50 10 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 5 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 1 000 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 1 study submitted
  • 1 study processed
P/RResults
NOAEC (rat): 18 mg/L air [2]

Study data: inhalation
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 1 study processed
P/RResults
NOAEL (rabbit): 2 500 mg/kg bw/day [1]

Study data: dermal
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: in vivo
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
Study data: developmental
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 1 000 mg/kg bw/day (subchronic, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 1 000 mg/kg bw/day (subacute, rat)

Neurotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant