Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 619-598-5 | CAS number: 915095-87-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 August - 12 October 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2007
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- (3S)-3-[4-(2-chloro-5-iodobenzoyl)phenoxy]oxolane
- EC Number:
- 619-598-5
- Cas Number:
- 915095-87-3
- Molecular formula:
- C17 H14 Cl I O3
- IUPAC Name:
- (3S)-3-[4-(2-chloro-5-iodobenzoyl)phenoxy]oxolane
- Details on test material:
- - Name of test material (as cited in study report): IN00078281 (IN 78281)
- Physical state: White powder
- Analytical purity: The Certificate of Analysis was provided to the Study Director
- Purity test date:
- Lot/batch No.: 7889-058-10 (Exp. Dec 2006)
- Expiration date of the lot/batch:
- Supplier: Boehringer Ingelheim Pharmaceuticals
- Stability under test conditions: Stability data on bulk test material was not provided to the Study Director
- Storage condition of test material: Room Temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories
- Age at study initiation: 9-11 weeks
- Weight at study initiation: 176-290 grams
- Fasting period before study: overnight
- Housing: Animals were group housed by sex upon receipt and individually housed upon assignment to study
- Diet (e.g. ad libitum): ad libitum, Harlan Teklad Rodent Diet (certified)
- Water (e.g. ad libitum): ad libitum, tap water
- Acclimation period: minimum 5 days prior dosing
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 to 23°C
- Humidity (%): 27 to 72%
- Air changes (per hr): The room in which the animals were kept was documented in the study records.
- Photoperiod (hrs dark / hrs light): 12 hours light/12 hours dark
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5 % hydroxyethylcellulose in deionized water
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): 10 ml/kg - Doses:
- 300, 2000 mg/kg bw
- No. of animals per sex per dose:
- 12; three male and three female animals per dose were used
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations were performed at approximately 30 minutes, 1 and 4 hours (+-15 minutes) after dosing and once daily through day 15. Signs of toxicity were recorded as they are observed including the time of onset, degree and duration. Body weights were measured on Days 1 (fasted), 8 and 15
- Necropsy of survivors performed: yes
- Other examinations performed: mortality daily - Statistics:
- None performed
Results and discussion
- Preliminary study:
- All animals received for this study were assessed as to their general health by a member of the veterinary staff or other authorized personnel. During the acclimation period, each rat was observed at least once daily for any abnormalities or for the development of infectious disease. Only animals that were determined suitable for use were assigned to this study.
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No moratily was observed in the animals at 300 or 2000 mg/kg.
- Clinical signs:
- other: No clinical signs observed in the animals at 300 or 2000 mg/kg.
- Body weight:
- other body weight observations
- Remarks:
- all animals at 300 or 2000 mg/kg gained weight throughout the study
- Gross pathology:
- No visible lesions were observed in any of the animals at 300 or 2000 mg/kg at terminal necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified acc. to CLP
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The test item administered orally at a dose level of 2000 mg/kg body weight in male and female rats was considered to be a Category 5 test substance with an LD50 greater than 2000mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.