Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 253-057-0
CAS number: 36483-57-5
Bacterial mutation assay (Ames test): FR-513 showed no evidence
of mutagenic activity in the absence or presence of rat S-9 mix. FR-513
showed clear evidence of mutagenic activity between 500 and 15 µg/plate
with strains TA 1535 and TA 100 in the presence of hamster S-9 mix.
Mouse lymphoma: FR-513 is mutagenic in the TK mutation test
system under the experimental conditions described in the report. The
mutagenicity was confirmed only to incubations in the presence of
Chromosome aberration: FR-513 was found to be clastogenic in the
presence of metabolic activation and at the highest test substance
concentration (1000 microgram/ml) in the absence of metabolic
activation. FR-513 has the potential to disturb mitotic processes and
cell cycle progression.
Micronucleus assay:FR-513 did not induce micronuclei as
determined by the micronucleus test with bone marrow cells of the mouse.
Therefore FR-513 can be considered to be non - mutagenic in this test.
UDS assay: FR-513 did not induce any marked or toxicologically
significant increases in the incidence of cells undergoing unscheduled
DNA synthesis in isolated rat hepatocytes following in vivo exposure for
2 or 16 hr. Therefore, the test material was considered to be
non-genotoxic under the conditions of the study.
Based on the results of the in vivo studies which were negative FR-513 .
Based on the information gained, the test substance Dibromoneopentyl
glycol can be considered non mutagenic ans does not need to be
classified according to Directive 67/548/EEC or Regulation (EC) No
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Tato webová stránka používá cookies, aby se vám naše stránky používaly co nejlépe.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again