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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

14 day repeated dose Oral toxicity test 
NOAEL= 1000 mg/kg bw/day (females); 300 mg/kg bw/day (males)
30 day feeding study with FR-1360:
NOAEL= 300 mg/kg bw/day (females); 30 mg/kg bw/day (males)

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
30 mg/kg bw/day
Study duration:

Additional information

14 day Oral toxicity test: It is concluded that daily oral gavage administration of Trinol to CD rats at

doses up to 1000 mg/kg/day in females and 300 mg/kg/day in males was well tolerated and

these doses are considered to be the no-observed-adverse-effect-level (NOAEL). However,

doses of 1000 mg/kg/day in males necessitated premature sacrifice of these animals on Day 4

and was considered to exceed the maximum tolerated dose.

30 day dietary feeding study with FR-1360: Ingestion of up to 30 mg/kg/day of FR-1360 in the diet of rats for 30 days did not cause changes in the toxicological parameters evaluated (NOAEL = 30 mg/kg/day). At levels of 100 and 300 mg/kg/day, histologic changes in kidney and urinary bladder were noted in male rats. No changes were noted in any of the female rats in this study.

Justification for classification or non-classification

Based on the information gained, the test substance Tribromoneopentyl glycol does not need to be classified for repeated dose toxicity according to Directive 67/548/EEC or Regulation (EC) No 1272/2008.