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EC number: 253-057-0
CAS number: 36483-57-5
see attached document on tables
Acute oral toxicity with FR-513 in the rat was carried out using
appropriate guidelines of OECD 423, OPPTS 870.1100.
FR-513 was administered by oral gavage to two subsequent groups of three
female Wistar rats at 2000 mg/kg body weight.
Animals were subjected to daily observations and weekly determination of
body weight. Macroscopic examination was performed after terminal
sacrifice (day 15). The incidance of mortality was 1/3 based on two
observations. Lethargy, restless behaviour, hunched posture,
ventro-lateral recumbency, flat gait, uncoordinated movements, laboured
respiration, piloerection, salivation, ptosis, squeaking, and/or
hypothermia were noted among animals between days 1 and 3. The body
weight was considered normal and no abnormalities were found at
macroscopic post mortem examination of the animals. The oral LD50 value
of FR-513 in Wistar rats was established to exceed 2000 mg/kg body weight
According to the OECD 423 test guideline the LD50 cut-off value was
considered to be 2500 mg/kg body weight.
Based on the results FR-513 is considered not classified.
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