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EC number: 253-057-0
CAS number: 36483-57-5
Acute Oral toxicity study to ratsAcute dermal toxicity study to rats
oral toxicity in rats:
Mortality was observed in 1 out of 3 female rats in two separate
observations following oral administration of FR-513 at 2000 mg/kg.
Lethargy, restless behavior, hunched posture, ventro-lateral recumbency,
flat gait, uncoordinated movements, labored respiration, piloerection,
salivation, ptosis, squeaking, and/or hypothermia were noted among
animals between days 1 and 3. No
abnormalities were found and body weight gain was considered to be
oral LD50 of the test material is judged to be greater than 2000 mg/kg
in female rats.
dermal toxicity to rats :
No mortality observed. Lethargy, flat posture, hunched posture,
piloerection, ptosis, red urine, chromodacryorrhoea and/or shallow
respiration were noted among the animals. The animals had recovered from
the symptoms by day 5. General or maculate erythema, necrosis, scales,
scars and/or scabs were seen in the treated skin-area of the animals
during the observation period. No abnormalities occurred and body weight
gain was considered to be normal. The dermal LD50 value FR-513 in Wistar
rats was established to exceed 2000 mg/kg body weight.
FR-513 is not expected to be available through the inhalation route,
since the substance is a solid, in a flakes form (not powder), with a
very low estimated vapour pressure.
Based on the high LD50 values for the oral and dermal exposure, together
with the unlikelyhood for inhalation exposure of the substance, FR-513
does not need to be classified for acute toxicity under the EEC criteria
for classification and labelling requirements for Dangerous Substances
and Preparations (67/548/EEC) and the CLP Regulation (EC No 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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