Registration Dossier
Registration Dossier
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EC number: 601-329-8 | CAS number: 114798-26-4
Phototransformation in water
Administrative data
Link to relevant study record(s)
Description of key information
Losartan is susceptible to aqueous photolysis and degrades rapidly under clear sky conditions. Two photodegradates are formed during photolysis; one less polar than the parent compound; one more polar than the parent compound. The maximum half-life for Losartan is less than 18 hours (at pH 9) in direct sunlight. The half-life at pH 7 was 11.8 hrs with a rate constant of 0.0587 / hr. Therefore, by read-across, losartan free acid has a photolytical half life of <18hrs in aqueous conditions.
Key value for chemical safety assessment
- Half-life in water:
- 18 h
Additional information
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