Registration Dossier
Registration Dossier
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EC number: 221-255-6 | CAS number: 3047-33-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Read-across:
1. Based on the experimental results obtained with the analogue cyanuric acid (stimulation index of ≤ 3) (based on the severity of the response the positive results were considered indicators of borderline or mild skin sensitization potential) and the molecular weights, the read-across approach is applied and the same results can be extrapolated to substance trisodium cyanurate.
Migrated from Short description of key information:
Read-across from a LLNA assay performed with cyanuric acid
Justification for classification or non-classification
The results of the LLNA study (Kuhn JO 2008) indicated that CYA elicited a positive response for potential skin sensitization, based on test/vehicle control ratio or stimulation index (SI) of 3 or greater in two of the three concentrations tested (50% and 100%). These positive results were considered indicators of borderline or mild skin sensitization potential. The test group at 25% CYA was below the SI of 3 threshold for a positive response. The severity of response was low, just above the SI threshold of 3 for only two of the three concentrations tested, which were considered borderline positive. In addition, the response at 25% CYA was below this threshold and not considered a positive response. On this basis CYA should not be classified as a skinsensitizer.
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