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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1977
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: An old publication with few details on the method used.

Data source

Materials and methods

Principles of method if other than guideline:
No data available.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male
Details on test animals or test system and environmental conditions:
200 - 300 g body weight.
Mice were also used: Strain CF-1, male, 22-28 g.

Administration / exposure

Route of administration:
inhalation: gas
Type of inhalation exposure:
whole body
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
1 h

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LC50
Effect level:
2 541 ppm
Based on:
test mat.
95% CL:
2 243 - 2 878
Exp. duration:
1 h
Remarks on result:
other: For rats.
Sex:
male
Dose descriptor:
LC50
Effect level:
4 418 ppm
Based on:
test mat.
95% CL:
3 940 - 4 953
Exp. duration:
1 h
Remarks on result:
other: For mice.
Mortality:
No data are available.
Clinical signs:
other: No data are available.
Body weight:
No data are available.
Gross pathology:
No data are available.
Other findings:
No data are available.

Any other information on results incl. tables

For the original results see the attachment.

Applicant's summary and conclusion

Conclusions:
An LC50,1h of 2541 ppm was obtained from an experiment with the BCl3-gas and rats..
Executive summary:

An acute inhalation toxicity study with rats was performed with a lot of substances. Mice were used too. For boron trichloride an LC50,1h,rat = 2541 ppm was obtained.