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EC number: -
CAS number: -
Five male and five female HanRcc:WIST (SPF) rats were treated with FP-100 at 2000 mg/kg by dermal application. The test item was diluted in vehicle (olive oil) at a concentration of 0.5 g/mL and administered at a volume dosage of 4 mL/kg. The application period was 24 hours.
The animals were examined daily during the acclimatization period and mortality, viability and clinical signs were recorded. All animals were examined for clinical signs at approximately 30 minutes, 1, 2, 3 and 5 hours after treatment on day 1 and once daily during test days 2-15. Local signs were noted once daily from test day 2 to 15. Mortality/viability was recorded at approximately 30 minutes, 1, 2, 3 and 5 hours after administration on test day 1 (with the clinical signs) and twice daily during days 2-15. Body weights were recorded on day 1 (prior to administration) and on days 8 and 15. All animals were necropsied and examined macroscopically.
No deaths occurred during the study.
Nine animals showed a slight erythema beginning at test day 2 after removal of the dressing and persisting as slight until test day 4. In one animal the slight general erythema was present from the 2-day reading and persisted until 6 days after treatment. This animal showed additionally crusts from test day 4 till test day 12.
One animal showed a slight loss of weight (1.9%) at day 8, the animal recovered until the end of the study. The body weight of the other animals was within the range commonly recorded for this strain and age
No macroscopic findings were observed at necropsy.
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