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EC number: -
CAS number: -
Two groups, each of three female HanRcc:WIST (SPF) rats, were treated with FP-100 by oral gavage administration at a dosage of 2000 mg/kg body weight. The test item was diluted in vehicle (olive oil) at a concentration of 0.2 g/mL and administered at a dosing volume of 10 mL/kg.
The animals were examined daily during the acclimatization period and mortality, viability and clinical signs were recorded. All animals were examined for clinical signs at approximately 30 minutes, 1, 2, 3 and 5 hours after treatment on day I and once daily during test days 2-15. Mortality/viability was recorded at approximately 30 minutes, 1, 2, 3 and 5 hours after administration on test day I (with the clinical signs) and twice daily during days 2-15. Body weights were recorded on day I (prior to administration) and on days 8 and 15. All animals were necropsied and examined macroscopically.
All animals survived until the end of the study period.
All the animals showed a slightly ruffled fur which was present in the first three treated animals approximately 20 minutes after treatment up to the 5-hour reading and in the other three further animals from the 1-or 2-hour reading to the 5 hours post-dose.
The body weight of the animals was within the range commonly recorded for this strain and age.
No macroscopic findings were recorded at necropsy.
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