Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
melting point/freezing point
Remarks:
melting point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2020
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020
Report date:
2020

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
GLP compliance:
not specified
Type of method:
thermal analysis

Test material

Constituent 1
Chemical structure
Reference substance name:
L-arginine phosphate
EC Number:
949-986-2
Cas Number:
49720-39-0
Molecular formula:
C6H19N4O7P
IUPAC Name:
L-arginine phosphate
Test material form:
solid: crystalline
Remarks:
particulate/powder

Results and discussion

Melting / freezing point
Key result
Decomposition:
yes
Decomp. temp.:
ca. 125 - ca. 400 °C
Remarks on result:
other: no determation of melting point possible. The substance decomposes.

Applicant's summary and conclusion

Conclusions:
L-arginine phosphate monohydrate has been characterized by thermal analysis as advised in OECD Guideline 102, point 8, Table 1, aiming to determine its melting point and facilitate calculation of vapour pressure. The presented results clearly demonstrate that L-arginine phosphate monohydrate decomposes in three distinct stages between approximately 125 °C – 400 °C (see Figure 1 and Figure 2 in the report) rather than display specific melting points. Hence, a melting point cannot be determined due to decomposition.