Registration Dossier
Registration Dossier
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EC number: 947-918-6 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Additional information
Reaction product of 1,3,5-Triazine-2,4,6-triamine, polymer with formaldehyde, methylated and C16-18 fatty alcohols is characterised by low water solubility (< 15 µg/L at 20 °C and pH 6.3; OECD 105), a low volatilization potential (vapour pressure < 0.0001 Pa at 20 °C, Mpbpwin v.1.43) and a high adsorption potential to soil and sediment particles (log Koc: 3.58 – 12.45, MCI, KOCWIN v2.00). The substance is not readily biodegradable (11 % biodegradation after 28 days; OECD 301B). However, due to the high adsorption potential of the substance, a removal from the water column to a significant degree by adsorption to sewage sludge can be expected (Guidance on information requirements and chemical safety assessment, Chapter R.7b, (ECHA, 2017)). Thus, only limited amounts will get in contact with activated sludge organisms in STPs and the concentration of the substance in effluents of conventional STPs is presumably marginal.
If released into the environment, sediment and soil are expected to be the main compartments for environmental distribution. Since the substance is not volatile (vapour pressure < 0.0001 Pa at 20 °C, Mpbpwin 1.43), evaporation to the air and transport through the atmospheric compartment is not likely. Indirect photodegradation in air is therefore not relevant. Abiotic hydrolysis is not relevant as the substance is highly insoluble in water (< 15 µg/L at 20 °C and pH 6.3; OECD 105).
In an organism, the highly lipophilic character of the substance indicates a tendency to distribute into cells, particularly fatty tissues. This tendency is, however, reduced by the high molecular weight of the substance which significantly reduces the absorption due to steric hindrance to cross biological membranes. If the substance is taken up by an organism, oral absorption is the most likely route. The substance is enzymatically metabolised, yielding hydroxylated breakdown products that are further metabolised in the liver and ultimately excreted via urine. Bioaccumulation in organisms is therefore considered very low. This is further supported by calculated BCF values, none of which raise concern over bioaccumulative behaviour. Long term data with mammals did furthermore not show any toxicity effects supporting the assumption of a low bioaccumulation potential from the substance. Taking all this information into account, it can be concluded in a weight of evidence approach that the bioaccumulation of Reaction product of 1,3,5-Triazine-2,4,6-triamine, polymer with formaldehyde, methylated and C16-18 fatty alcohols is low.
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