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EC number: 219-976-6
CAS number: 2589-57-3
in vitro Guideline studies for skin and eye irritation available.
After treatment with the test item, the relative absorbance values were
reduced to 11.8 %. This value is well below the threshold for eye
irritation potential (≤ 60 %). All validity criteria were met. The
criterion for optical density of the negative control was fulfilled: The
OD value was 1.8 (> 0.8 and < 2.5). The positive control induced a
decrease in the relative absorbance as compared to the negative control
to 38.5 %. Variation within the replicates was acceptable (< 20 %).
For these reasons the result of the test is considered as valid.
adverse effects on respiration are observed in an inhalatory acute
No effects are stated for the low-dose group (0.560 mg/L, aerosol).
For the mid-dose and high-dose groups it is stated:
Clinical signs of toxicity in animals exposed to 1.935 mg/L comprised
intermittent respiration, nasal red discharge and red encrusted nose,
salivation indicating a
local irritation effect.
Clinical signs of toxicity in animals exposed to 3.994 mg/L comprised
gasping respiration, intermittent and labored respiration indicating a
local irritation effect.
The available information is conclusive but not sufficient for
classification for skin irritation /corrosion.
The available information is conclusive and sufficient for
classification for eye irritation cat. 2.
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