Registration Dossier
Registration Dossier
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EC number: 219-976-6 | CAS number: 2589-57-3
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Version / remarks:
- 2008
- Deviations:
- yes
- Remarks:
- The test item storage temperature was exceeded (maximum temperature: 9.2 °C). This was considered uncritical, because the exceedance was only short term.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.47
- Temp.:
- 25 °C
- pH:
- > 6
- Conclusions:
- The log Pow of dimethyl-2,2'-azobisisobutyrate was calculated as 2.470 ± 0.002 (mean ± standard deviation)
Reference
The chromatogram of the test item gave two peaks. With the calibration function log K versus log POW, the corresponding log POW values were determined with:
Peak |
Mean Retention Time [min] |
Mean Relative Peak Area [%] |
logPow +/- Standard Deviation |
1 |
2.792 |
16.19 |
1.428 +/- 0.006 |
2 |
12.4128 |
83.66 |
2.470 +/- 0.002 |
Peak 1 with log POW 1.428 ± 0.006 is considered as impurity according to Substance identity report 15052207S001 ( LAUS GmbH)
Description of key information
The logPow was determined according to EU A.8 (resp. OECD 117), using the HPLC method. The log Pow of dimethyl-2,2'-azobisisobutyrate was calculated as 2.470 ± 0.002 (mean ± standard deviation).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.47
- at the temperature of:
- 25 °C
Additional information
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