Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 253-462-2
CAS number: 37321-62-3
Table 1. Results of the intradermal application (preliminary test).
After 24, 48 and 72 h, no skin reaction was observed in the test animals
in the concentration 2.5, 25 and 50% of the test substance. After 24 h
very slight erythema and oedema were observed in 2/4 animals being fully
reversible after 48 h.
- Bodyweight changes and systemic effects:
No toxic effects were observed in the treated animals during the
One animal died within 24 h after the dermal induction. Possibly, the
animal was too strongly bandaged resulting in dyspnoea and death.
Necropsy revealed a clear yellow liquid in the thorax and no further
abnormal organ findings.
- Results of the intradermal induction:
One h after injection of FCA all test and control animals showed
severe erythema and oedema. 11/20 test animals and 6/20 control animals
showed injuries in the depth. 24 h later all animals showed severe
erythema and oedema.
24 h after test substance injection all test animals showed slight
erythema and oedema comparable to the control animals. Injection of test
substance and FCA (1:1) induced moderate to strong erythema and moderate
oedema. After 24 h strong erythema with deep injuries in 8/20 test
animals and strong oedema were observed. Control animals injected with
50% FCA and corn oil showed 1 h after application well defined erythema
and slight oedema. 24 h post application severe erythema with deep
injuries (3/20) and strong oedema were observed.
- Results of the dermal induction:
Due to the use of SDS the shoulder region was reddened and swollen
at Day 7. All test and control animals treated with FCA showed 49 h post
application severe erythema with deep injuries and eschar formation and
severe oedema. After 72 h the application sites of all animals were
swollen and eschar formation was apparent. The animals treated with test
substance in the vehicle showed scale formation at 49 and 72 h post
Animals treated with the test substance in FCA showed severe
erythema with injuries in the depth and strong oedema at 49 and 72 h
after application. The control animals showed comparable reaction at the
- Results of the challenge application:
None of the test animals and none of the control animals showed a
skin reaction 48 and 72 h post application.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Tato webová stránka používá cookies, aby se vám naše stránky používaly co nejlépe.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again