Registration Dossier
Registration Dossier
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EC number: 949-084-9 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Peer-reviewed publication, 1984, described in good detail
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute toxicity of vanadium compounds in rats and mice
- Author:
- J Llobet and J Domingo J L
- Year:
- 1 984
- Bibliographic source:
- Toxicology Letters, 23: 227 - 231
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- Males only
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Vanadium oxide sulphate
- EC Number:
- 248-652-7
- EC Name:
- Vanadium oxide sulphate
- Cas Number:
- 27774-13-6
- Molecular formula:
- V(IV) O (SO4)
- IUPAC Name:
- Vanadium IV oxysulphate
Constituent 1
- Specific details on test material used for the study:
- Hydrated form used for testing.
Calculations made to consider effects of the water-free substance
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- Buffered to pH 7.4
- Details on oral exposure:
- Buffered to ca pH 7 to avoid local corrosivity effects
- Doses:
- 296, 395, 500, 650, and 845 mg/kg reported (hydrated material)
ca 207, 277, 350, 455 and 591 mg/kg of anhydrous material. - No. of animals per sex per dose:
- 10 males
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 290 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- The top dose of ca 590 mg/kg actives led to 10/10 mortality. Other dose levels showed reduced mortality and the lowest treatment level of 207 mg/kg had full survival.
- Clinical signs:
- other: The top dos caused ataxia, diarrhoea, irregular respiration and changes in cardiac rhythm. Clinical and physical signs typically appeared within 24 hours, and in surviving animals, had resolved 48 hours after administration.
- Gross pathology:
- Not reported
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Although precise details were not provided in the publication, the result allow for classification.
Further animal testing is not justified.
Only the rat data has been included in this summary.
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