Registration Dossier
Registration Dossier
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EC number: 201-132-3 | CAS number: 78-67-1
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity, other
- Remarks:
- intraperitoneal
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Title:
- No information
- Author:
- Hendry, J.A. et al.: Brit. J. Pharmacol. 6, 201-234 (1951);|cited in: TSCATS: OTS 0000937, Doc. ID. FYI-OTS-0794-0937,|Haskell Laboratory for E.I. Dupont de Nemours & Co., 1-30-84
Materials and methods
- Principles of method if other than guideline:
- inhibition of tumor growth
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2'-dimethyl-2,2'-azodipropiononitrile
- EC Number:
- 201-132-3
- EC Name:
- 2,2'-dimethyl-2,2'-azodipropiononitrile
- Cas Number:
- 78-67-1
- Molecular formula:
- C8H12N4
- IUPAC Name:
- 2,2'-dimethyl-2,2'-azodipropiononitrile
- Details on test material:
- IUCLID4 Test substance: no data
TS-Freetext:
2,2'-azobisisobutyronitrile; no data on purity of the
compound
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Duration of treatment / exposure:
- 10-12 days
- Frequency of treatment:
- daily
Doses / concentrations
- Dose / conc.:
- 800 mg/kg bw (total dose)
- Control animals:
- not specified
Results and discussion
Results of examinations
- Details on results:
- the test substance did not inhibit tumor growth by >45% and did not appear to have any effect that was directed preferentially towards the tumor
Any other information on results incl. tables
The test substance was tested for activity as a cytotoxic agent in a test using implants of the Walker tumor. A total dose of 800 mg/kg was administered in daily doses during the first 10-12 days following the tumor implantation. According to the authors, the test substance did not inhibit tumor growth by >45% and did not appear to have any effect that was directed preferentially towards the tumor. Only secondary literature; no further data.
Applicant's summary and conclusion
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