Registration Dossier
Registration Dossier
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EC number: 220-103-6 | CAS number: 2628-17-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- p-vinylphenol
- EC Number:
- 220-103-6
- EC Name:
- p-vinylphenol
- Cas Number:
- 2628-17-3
- Molecular formula:
- C8H8O
- IUPAC Name:
- p-vinylphenol
- Test material form:
- liquid
Constituent 1
Test system
- Vehicle:
- water
- Controls:
- yes
- yes, concurrent vehicle
- yes, concurrent positive control
- yes, concurrent negative control
Results and discussion
In vitro
Results
- Irritation parameter:
- cornea opacity score
- Run / experiment:
- Bovie corneal opacity
- Value:
- ca. 0
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Other effects / acceptance of results:
- The substance polymerised during the study.
Applicant's summary and conclusion
- Interpretation of results:
- other: substance polymerised during the study
- Conclusions:
- Cannot test for eye irritancy since p-vinyl phenol polymerises during the study.
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