Reaction mass of isomers of disodium amino-(3-carboxylatopropanamido)hexanoate and trisodium 2,6-bis(3-carboxylatopropanamido)hexanoate

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2017-09-19 to 2017-11-16

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7220 (Boiling Point / Boiling Range)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Key result

Boiling pt.:

>= 136 - <= 149 °C

Atm. press.:

99.34 kPa

Appearance of the substance

Before the test the appearance of the test item was highly viscous, semi-solid brown mass. After the experiments the test item was hardened and blackened in the crucible.

Table 1: Values of the DSC run in the first experiment

Sample weight [mg]	Loss of Mass of the Sample (%)	Onset of effect [°C]	Endset of effect [°C]	Peak Maxium [°C]	Energy [J/g]	Atmospheric Pressure (kPa)
18.28	72.7	138	150	143	-99 (endothermic)	99.32

 

Table 2: Values of the DSC run in the second experiment

Sample weight [mg]	Loss of Mass of the Sample (%)	Onset of effect [°C]	Endset of effect [°C]	Peak Maxium [°C]	Energy [J/g]	Atmospheric Pressure (kPa)
19.23	70.4	135	148	139	-92 (endothermic)	99.34

 

Table 3: Summary of the DSC Test of Test Item

	Experiment 1	Experiment 2	Mean
Onset of effect [°C]	138	135	136
Endset of effect [°C]	150	148	149

 

Conclusions:

Using a linear heating rate of 10 °C/min the boiling point of the test item was determined to be in the range of 136 - 149 °C (409 – 422 K) at atmospheric pressure.

Executive summary:

A study was conducted according to OECD TG 103, Regulation (EC) No 440/2008 method A.2 and EPA OPPTS 830.7220 to determine the boiling point of the test item using differential scanning calorimetry. The test item was weighed out into an aluminium crucible under an inert atmosphere (nitrogen). Two tests were performed. As reference crucible, an empty aluminium crucible was used. The substance is a highly viscous, semi-solid mass at ambient conditions. Using a linear heating rate of 10 °C/min the boiling point of the test item was determined to be in the range of 136 - 149 °C (409 – 422 K) at atmospheric pressure. After the test the test item was hardened and blackened in the crucible.

Description of key information

Using a linear heating rate of 10°C/min and differential scanning calorimetry, the boiling point of the test item was determined to be in the range of 136 - 149 °C (409 – 422 K) at atmospheric pressure.

Additional information

A study was conducted according to OECD TG 103, Regulation (EC) No 440/2008 method A.2 and EPA OPPTS 830.7220 to determine the boiling point of the test item using differential scanning calorimetry. The test item was weighed out into an aluminium crucible under an inert atmosphere (nitrogen). Two tests were performed. As reference crucible, an empty aluminium crucible was used. The substance is a highly viscous, semi-solid mass at ambient conditions. Using a linear heating rate of 10 °C/min the boiling point of the test item was determined to be in the range of 136 - 149 °C (409 – 422 K) at atmospheric pressure. After the test the test item was hardened and blackened in the crucible.