Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin corrosion: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
Hessisches Ministerium für Umwelt, Energie, Landwirtschaft und Verbraucherschutz

Test material

Constituent 1
Chemical structure
Reference substance name:
Copper(2+) tetrafluoroborate(1-)
EC Number:
253-959-4
EC Name:
Copper(2+) tetrafluoroborate(1-)
Cas Number:
38465-60-0
Molecular formula:
BF4.1/2Cu
IUPAC Name:
copper(2+) bis(tetrafluoroboranuide)
Constituent 2
Chemical structure
Reference substance name:
Water
EC Number:
231-791-2
EC Name:
Water
Cas Number:
7732-18-5
Molecular formula:
H2O
IUPAC Name:
water
Test material form:
other: 50% solution in water

In vitro test system

Test system:
artificial membrane barrier model
Source species:
other: proprietary biobarrier membrane
Cell type:
other: proprietary biobarrier membrane
Cell source:
other: proprietary biobarrier membrane
Source strain:
other: proprietary biobarrier membrane
Vehicle:
other: no vehicle use, solution
Control samples:
yes, concurrent negative control
yes, concurrent positive control

Results and discussion

In vitro

Results
Irritation / corrosion parameter:
other: time interval of colour change
Value:
13
Vehicle controls validity:
not examined
Negative controls validity:
valid
Positive controls validity:
valid
Remarks on result:
other: corrosive, GHS 1B

Applicant's summary and conclusion

Interpretation of results:
Category 1B (corrosive) based on GHS criteria
Conclusions:
Copper(II) fluoborate solution 50 % is corrosive to skin GHS cat 1b