Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin corrosion: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
Hessisches Ministerium für Umwelt, Energie, Landwirtschaft und Verbraucherschutz
Test system:
artificial membrane barrier model
Source species:
other: proprietary biobarrier membrane
Cell type:
other: proprietary biobarrier membrane
Cell source:
other: proprietary biobarrier membrane
Source strain:
other: proprietary biobarrier membrane
Vehicle:
other: no vehicle use, solution
Control samples:
yes, concurrent negative control
yes, concurrent positive control
Irritation / corrosion parameter:
other: time interval of colour change
Value:
13
Vehicle controls validity:
not examined
Negative controls validity:
valid
Positive controls validity:
valid
Remarks on result:
other: corrosive, GHS 1B
Interpretation of results:
Category 1B (corrosive) based on GHS criteria
Conclusions:
Copper(II) fluoborate solution 50 % is corrosive to skin GHS cat 1b
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vitro / ex vivo
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study need not be conducted because the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes
Reason / purpose for cross-reference:
reference to other study
Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification