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EC number: 222-048-3
CAS number: 3327-22-8
CHPTAC (65%) was tested negative for skin and eye irritation properties
in tests conducted according to OECD 404 and OECD 405.
In a study conducted according to EU
guideline, three New Zealand White rabbits received a 0.5ml dose of 65%
CHPTAC in water to a shaved region in the dorso-lumbar area. The test
substance was applied to an area of 2.5cm2. The patch was semi-occluded
with an adhesive dressing for 4 hours. After the removal of the
semi-occlusive dressing the application area was washed. The skin was
examined 30 minutes after the removal of the patches and on days 2,3 and
4. The scores were zero at all time points. The substance is not
irritating to rabbit skin.
Cornea: 0, 24, 72 h, 48 h: 1 animal: 1, 2 animals: 0, Iris:
0 (3 animals, 24, 48, 72 h),
Conjunctiva redness: 24 h: 2 (2 animals), 1 (1 animal)
48 h: 2 (3 animals)
72 h: 1 (3 animals)
After 4 and 7 days: 0 (3 animals).
Conjunctiva chemosis: 24 h: 2 (1 animal), 1 (2 animals)
48 h: 1 (3 animals)
72 h: 1 (2 animals), 0 (1 animal)
After 4 and 7 days: 0 (3 animals).
In a primary eye irritation study
(OECD 405), 0.1 mL of CHPTAC (65%) was instilled into the conjunctival
sac of one eye of each of three young adult New Zealand White rabbits.
Animals were observed for 7 days. Irritation was scored by the method
of Draize. Only very mild conjunctival reactions were observed, which
were fully reversible within 96 hours. In this study, the test item is
not an eye irritant.
The key skin
irritation study (Shell, 1987) was chosen from six studies, generating a
similar classification, as the most recent study. The key study was of
reliability 2 and the supporting studies comprised one of reliability 2,
three of reliability 3 (reliable with restrictions; an absence of GLP)
and one of reliability 4 (not assignable; very limited reports).
The key eye
irritation/corrosion study was identified from seven giving broadly
similar findings as the most recent study. The key study was of
reliability 2. Supporting studies (reliability 2,3 and 4), indicated
that the test material (55% or 60% CHPTAC or unspecified) was either
slightly irritant or non-irritant. One study (QUAS048, reliability 2)
produced results that were judged at the time to indicate a non-irritant
material . The balance of findings from other studies (many of good
quality) are that the test material (up to 65% CHPTAC, where specified)
would not be classified as an eye irritant.
In the case of skin
and eye irritation, it is not possible from the data identified to
determine what the effect of the pure (100%) material might be.
Based on the available data, no
classification for CHPTAC (65%) is warranted for skin and eye irritation.
the case of skin and eye irritation, it is not possible from the data
identified to determine what the effect of the pure (100%) material
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