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EC number: 241-026-4
CAS number: 16957-70-3
The mutagenic activity of the substance was evaluated according to OECD
guideline 471 and GLP principles. The test was performed in two
independent plate incorporation assays: one initial test to establish
the dose-range and one confirmatory test to evaluate and confirm the
mutagenic potential of the substance. The test was performed with and
without metabolic activation (S9 -mix) up to and including a
concentration of 5000 μg substance/plate. Adequate negative and positive
controls were included. The substance did not induce a significant
dose-related increase in the number of revertant (His+) colonies in each
of the four S. typhimurium tester strains (TA1535, TA1537, TA98 and
TA100) and in the number of revertant (Tryp+) colonies in E.coli
WP2uvrA, both in the absence and presence of S9-metabolic activation. No
precipitation or background lawn toxicity was observed. Reduction in
revertant counts was observed in both assays in test strains TA1535
(without S9 in the initial assay and with S9 in the confirmatory assay)
and WP2 uvrA (without S9 in the initial assay and with and without S9 in
the confirmatory assay). Based on the results of this study it is
concluded that the substance is not mutagenic in the Salmonella
typhimurium reverse mutation assay and not mutagenic in the Escherichia
coli reverse mutation assay.
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